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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1511607

Exploring the association between caffeine intake and benign prostatic hyperplasia: results from the NHANES 2005-2008

Provisionally accepted
Fei Zhang Fei Zhang Andong Zhang Andong Zhang Junyue Tao Junyue Tao Meng Zhang Meng Zhang *Chaozhao Liang Chaozhao Liang
  • First Affiliated Hospital of Anhui Medical University, Hefei, China

The final, formatted version of the article will be published soon.

    Background: Coffee is a physiologically active food component prevalent throughout the world, but the association between caffeine intake and benign prostatic hyperplasia (BPH) has been limited in extensive epidemiological studies.We conducted a cross-sectional study to evaluate the association between caffeine intake and BPH in adults in the United States using data from the National Health and Nutrition Examination Survey (NHANES) 2005-2008. Caffeine intake (mg/day) was evaluated based on a 24hour dietary recall. Multivariate logistic regression was used to analyze the independent relationship between caffeine intake and BPH, and the results are presented as odds ratio (OR) and 95% confidence interval (CI), subgroup analysis was also performed.Results: A total of 2,374 participants were analyzed. After fully adjusting for potential confounders, logistic regression analysis revealed that higher caffeine intake was associated with a greater risk of BPH (ORT3vs1=1.52, 95% CI: 1.01-2.27; P=0.04). In addition, this relationship was consistently observed across different subgroups, including individuals with lower education levels, a poverty income ratio (PIR) of 1.5 to 3.5, former smokers, married/living with partner individuals, those with uric acid levels of 5.5 to 6.5 mg/dL, those with hypertension, and those without cardiovascular disease (CVD).This study is the first to find a positive correlation between caffeine intake and BPH, but further research is needed to determine the 4 exact causal relationship between these factors.

    Keywords: Caffeine intake, Coffee, Benign prostatic hyperplasia, NHANES, Men's Health

    Received: 15 Oct 2024; Accepted: 12 Dec 2024.

    Copyright: © 2024 Zhang, Zhang, Tao, Zhang and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Meng Zhang, First Affiliated Hospital of Anhui Medical University, Hefei, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.