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CLINICAL TRIAL article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 |
doi: 10.3389/fnut.2024.1510318
This article is part of the Research Topic Dietary Patterns and Oxidative Stress: Implications for Obesity, T2D, and Cancer Management View all 3 articles
Effect of synbiotic supplementation on obesity and gut microbiota in obese adults: a double-blind randomized controlled trial
Provisionally accepted
晓康 牛
1
Qi Zhang
1*
Julong Liu
2*
Yuyang Zhao
1*
Nan Shang
1
Shusen Li
2*
Yinghua Liu
3
Wei Xiong
4
Erna Sun
2*
Yong Zhang
3
Hongfeng Zhao
2*
Yixuan Li
1
Pengjie Wang
1
Bing Fang
1
Liang Zhao
1
Juan Chen
1*
Fuqing Wang
5*
Guofang Pang
6*
Chenyuan Wang
2*
Jingjing He
1*
Ran Wang
1*- 1 China Agricultural University, Beijing, China
- 2 Mengniu Hi-Tech Dairy Product Beijing Co., Ltd, Beijing, China
- 3 Department of Nutrition, The First Medical Center of Chinese PLA General Hospital, Beijing, China
- 4 Food Laboratory of Zhongyuan, Luohe, China
- 5 Tibet Tianhong Science and Technology Co., Ltd, Lhasa, China
- 6 Chinese Academy of Inspection and Quarantine (CAIQ), Beijing, Beijing Municipality, China
Background: Synbiotics, combining specific probiotics and selected prebiotics, may benefit health issues like obesity, but evidence remains inconsistent. Objective: This study aimed to verify the effect of a pre-screened synbiotics combination (containing Bifidobacterium animalis subsp. lactis MN-Gup (MN-Gup), galacto-oligosaccharides (GOS) and xylo-oligosaccharides (XOS)) on obesity in the population. Methods: In a randomized, double-blind, placebocontrolled trial, 80 individuals with obesity consumed daily synbiotics (containing MN-Gup 1 × 10 11 CFU/day, GOS 0.7g/day, and XOS 0.7g/day) or placebo for 12 weeks. Body composition, blood lipids, serum hormone, bile acids, and gut microbiota were measured preand post-intervention. Results: Synbiotics supplementation significantly decreased body fat percentage, waist, and serum low-density lipoprotein cholesterol (LDL-C), increased peptide YY, cholecystokinin, oxyntomodulin, GSH (glutathione peroxidase) in individuals with obesity. Additionally, synbiotic supplementation led to an enrichment of beneficial bacteria and bile acids (Chenodeoxycholic Acid (CDCA). Bifidobacterium and Romboutsia were significantly positively correlated with CDCA. A more favorable effect was observed in individuals with obesity and abnormal LDL-C compared to those without dyslipidemia. Conclusion: 12-week synbiotics intervention reduced body fat percentage, waist, and serum LDL-C, especially in individuals with obesity and abnormal LDL-C. The possible mechanisms may be related to changes in gut microbiota, bile acids and gut hormones. The study was registered at Chictr.org.cn with a registration number of ChiCTR2200064156.
Keywords: Bifidobacterium animalis subsp. lactis MN-Gup, Synbiotics, Obesity, Gut Microbiota, randomized controlled trial
Received: 12 Oct 2024; Accepted: 15 Nov 2024.
Copyright: © 2024 牛, Zhang, Liu, Zhao, Shang, Li, Liu, Xiong, Sun, Zhang, Zhao, Li, Wang, Fang, Zhao, Chen, Wang, Pang, Wang, He and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qi Zhang, China Agricultural University, Beijing, China
Julong Liu, Mengniu Hi-Tech Dairy Product Beijing Co., Ltd, Beijing, China
Yuyang Zhao, China Agricultural University, Beijing, China
Shusen Li, Mengniu Hi-Tech Dairy Product Beijing Co., Ltd, Beijing, China
Erna Sun, Mengniu Hi-Tech Dairy Product Beijing Co., Ltd, Beijing, China
Hongfeng Zhao, Mengniu Hi-Tech Dairy Product Beijing Co., Ltd, Beijing, China
Juan Chen, China Agricultural University, Beijing, China
Fuqing Wang, Tibet Tianhong Science and Technology Co., Ltd, Lhasa, China
Guofang Pang, Chinese Academy of Inspection and Quarantine (CAIQ), Beijing, Beijing Municipality, China
Chenyuan Wang, Mengniu Hi-Tech Dairy Product Beijing Co., Ltd, Beijing, China
Jingjing He, China Agricultural University, Beijing, China
Ran Wang, China Agricultural University, Beijing, China
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