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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1509711
This article is part of the Research Topic Micronutrients and Metabolic Diseases-Volume II View all 7 articles

Body Mass Index mediates the associations between Dietary Approaches to Stop Hypertension and Obstructive sleep apnea among U.S. adults

Provisionally accepted
Songtao Li Songtao Li 1*Yuxin Yang Yuxin Yang 2*Mengying Lin Mengying Lin 3*Tian Lv Tian Lv 4Yourang Pan Yourang Pan 3*Jie Zhou Jie Zhou 4*
  • 1 Department of Psychiatry, Shaoxing Seventh People’s Hospital, Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China
  • 2 School of Medicine, Shaoxing University, Shaoxing, Zhejiang Province, China
  • 3 Department of Psychosomatic, Shaoxing Seventh People’s Hospital, Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China
  • 4 Department of Neurology, Zhuji Affiliated Hospital of Wenzhou Medical University, Shaoxing, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    The Dietary Approaches to Stop Hypertension (DASH) are associated with reduced cardiovascular, diabetes risk, but the effect on obstructive sleep apnea (OSA) is uncertain. This study used data from the National Health and Nutrition Examination Survey (NHANES). DASH score was assessed through 24-h dietary recall interviews, and OSA diagnosis in individuals was based on predefined criteria. Logistic regression analysis was used to assess the association between DASH and OSA. Restricted cubic spline (RCS) analysis was used to investigate the dose-response relationship between DASH score and OSA risk. And comprehensive subgroup and mediation analyses were performed. Among the 14,978 participants, 27.01% had OSA. DASH scores had a negative association with the risk of OSA (OR=0.91, 95%CI: 0.88-0.95, p < 0.01). Next, we divided DASH scores into quintiles groups. In comparison to the reference group Q1, groups Q5 had adjusted OR values of 0.63 (95%CI: 0.52–0.76, p < 0.01). Subgroup analyses revealed that this association was consistent across different groups. Further mediation analyses showed that the associations of DASH with OSA risk parallelly mediated by the above Body Mass Index (BMI) 33.4% ,95%CI (20.6%-46.2%) (all p < 0.05). The restricted cubic spline (RCS) analysis indicated a significant dose-response relationship between DASH diet and OSA risk. These findings suggested that DASH decreased OSA risk, which was possibly and partly mediated by BMI.

    Keywords: OSA (Obstructive sleep apnea), DASH (Dietary Approaches to Stop Hypertension), NHANES (National Health and Nutrition Examination Survey), BMI - body mass index, Mediation

    Received: 11 Oct 2024; Accepted: 03 Dec 2024.

    Copyright: © 2024 Li, Yang, Lin, Lv, Pan and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Songtao Li, Department of Psychiatry, Shaoxing Seventh People’s Hospital, Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China
    Yuxin Yang, School of Medicine, Shaoxing University, Shaoxing, Zhejiang Province, China
    Mengying Lin, Department of Psychosomatic, Shaoxing Seventh People’s Hospital, Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China
    Yourang Pan, Department of Psychosomatic, Shaoxing Seventh People’s Hospital, Affiliated Mental Health Center, Medical College of Shaoxing University, Shaoxing, Zhejiang, China
    Jie Zhou, Department of Neurology, Zhuji Affiliated Hospital of Wenzhou Medical University, Shaoxing, Zhejiang Province, China

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