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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrigenomics
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1505636

Association Between Copper and Achilles tendon disease: A Two-Sample Mendelian Randomization Study

Provisionally accepted
Tianyang Chen Tianyang Chen *Yan Gu Yan Gu Zihao Zhang Zihao Zhang Zhaoliang Chen Zhaoliang Chen Jingquan Zhang Jingquan Zhang Xiangyang Leng Xiangyang Leng *
  • Changchun University of Chinese Medicine, Changchun, China

The final, formatted version of the article will be published soon.

    Background: There is a clear association between micronutrients and Achilles tendon disease(AT). An increase in micronutrients may alleviate AT symptoms and have a therapeutic effect. The aim of this study is to clarify the causal relationship between 15 micronutrients (copper, zinc, magnesium, vitamins A, C, E, D, B6, B12, folic acid, carotene, iron, selenium, calcium, and potassium) and AT.We employed the Mendelian Randomization (MR) method to analyze the causal effects of micronutrients on the risk of AT. The SNPs related to micronutrients were obtained from a large-scale genome-wide association study (GWAS) of circulating micronutrients in European populations. Outcome data were obtained from a meta-analysis of AT in European-ancestry participants from the Finnish FINNGEN BIOBANK. The main analysis was conducted using the inverse variance weighting (IVW) method, with additional sensitivity and pleiotropy analyses performed.Results: IVW results indicated a causal relationship between copper and AT (P: 0.003, OR=0.899, 95% CI = 0.839-0.964). Sensitivity analysis validated the robustness and reliability of this finding.This study revealed a causal relationship between copper and AT, with copper serving as a protective factor. This provides evidence of the causality between copper and AT, offering new insights for clinical research and therapeutic approaches in AT.

    Keywords: Achilles tendon disease, Mendelian Randomization Analysis, Copper, Micronutrients, Causal research

    Received: 03 Oct 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Chen, Gu, Zhang, Chen, Zhang and Leng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Tianyang Chen, Changchun University of Chinese Medicine, Changchun, China
    Xiangyang Leng, Changchun University of Chinese Medicine, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.