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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Immunology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1501685
This article is part of the Research Topic Dietary Bioactive Compounds as Coadjuvants in Antiviral Preventive and Curative Strategies View all articles

Formononetin and Mizoribine Inhibit Porcine Reproductive and Respiratory Syndrome Virus Replication In Vitro

Provisionally accepted
占鼎 崔 占鼎 崔 *
  • Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

The final, formatted version of the article will be published soon.

    This study delves into the antiviral efficacy of Formononetin (FMN) and Mizoribine (MZR) against the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), a virus with a considerable economic impact and a current void in effective treatments. FMN and MZR were found to inhibit various PRRSV strains in vitro, predominantly in the early stages of viral infection. Noteworthy was the observation of their synergistic effects when combined with Ribavirin. The study underscores the antiviral potential of FMN and MZR, particularly emphasizing their low cytotoxicity at specific concentrations. These results position FMN and MZR as promising antiviral agents against PRRSV, underscoring their low cytotoxicity and efficacy in early-stage viral inhibition. Such findings pave the way for their potential inclusion in future PRRSV management strategies.

    Keywords: Porcine Reproductive and Respiratory Syndrome, Formononetin, Antiviral agent, mizoribine, Swine Viral Infections

    Received: 25 Sep 2024; Accepted: 09 Dec 2024.

    Copyright: © 2024 崔. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: 占鼎 崔, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.