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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Microbes
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1499196

Regulation of intestinal flora by Suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitus

Provisionally accepted
Xuemei Yin Xuemei Yin 1Yinzi Sui Yinzi Sui 1Zhengyan Chu Zhengyan Chu 1Suqing Han Suqing Han 1Xiaodong Ge Xiaodong Ge 1Tingting Liu Tingting Liu 2Feng Zeng Feng Zeng 3Ligen Chen Ligen Chen 1Rong Shao Rong Shao 1Wei Xu Wei Xu 1*
  • 1 Yancheng Institute of Technology, Yancheng, Jiangsu, China
  • 2 Yancheng Second People's Hospital, Yancheng, China
  • 3 Fujian Agriculture and Forestry University, Fuzhou, Fujian Province, China

The final, formatted version of the article will be published soon.

    Type 2 diabetes mellitus (T2DM) often leads to elevated blood glucose levels and lipid metabolism disorder, which is generally accompanied by dysbiosis of gut microbiota and metabolic dysfunction. In this study, a mouse model of T2DM was established by feeding a high-fat/sucrose diet combined with injecting a low dose of streptozotocin. The aim of this study was to analyze the regulatory effect of Suaeda salsa extract (SSE) on T2DM and its effect on the intestinal flora of mice. The results showed that SSE could significantly improve the body weight, fasting blood glucose (FBG), area under the curve (AUC) of the oral glucose tolerance test (OGTT), glycosylated serum protein (GSP) and islet function index. Moreover, 4-week body weight, FBG, AUC of OGTT, GSP, as well as intestinal acetic and butyric acid were significantly better in the SSE-L than in the MET group (p < 0.05). In addition, it was also found that the potential hypoglycemic mechanism of SSE was related to the expression of Akt serine/threonine kinase (AKT-1) and glucose transporter-2 (GLUT-2) genes. Compared with the model group, SSE intervention significantly increased the abundance of probiotics, such as Soleaferrea, Alloprevotella, Lactobacillus and Faecalibaculum, while decreasing the relative abundance of harmful bacteria, such as Phocaeicola and Bilophila. Analysis of the correlation among intestinal microbiota, short chain fatty acids (SCFAs) and the hypoglycemic index showed that Dwaynesavagella was significantly correlated with acetic, propionic and butyric acid, as well as all the diabetes-related indexes analyzed in this study. Thus, this taxon can potentially be used as a microbiological marker of type 2 diabetes. Taken together, these findings demonstrate that SSE can alleviate T2DM and its complications by improving glycemia-related indicators and modulating the structure of intestinal flora.

    Keywords: Suaeda salsa extract, T2DM, Hyperglycemia, metabolic dysfunction, intestinal flora

    Received: 20 Sep 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Yin, Sui, Chu, Han, Ge, Liu, Zeng, Chen, Shao and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wei Xu, Yancheng Institute of Technology, Yancheng, 224051, Jiangsu, China

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