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PERSPECTIVE article

Front. Nutr.
Sec. Nutrition and Sustainable Diets
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1497953
This article is part of the Research Topic Bioactive Compounds from Medicinal Mushrooms and Plants - Extraction and Potential Application in Foods View all 5 articles

Harnessing the nutraceutical and therapeutic potential of Allium spp.: Current insights and future directions

Provisionally accepted
Kalyani Gorrepati Kalyani Gorrepati 1*Ram Krishna Ram Krishna 2Saurabh Singh Saurabh Singh 3Dhananjay V. Shirsat Dhananjay V. Shirsat 1Soumia P. S. Soumia P. S. 1*Vijay Mahajan Vijay Mahajan 1
  • 1 ICAR-Directorate of Onion and Garlic Research, Rajgurunagar, Pune, India
  • 2 Indian Institute of Vegetable Research (ICAR), Varanasi, Uttar Pradesh, India
  • 3 Institute of Environment and Sustainable Development, Banaras Hindu University, Varanasi, Uttar Pradesh, India

The final, formatted version of the article will be published soon.

    Apart from the culinary usage, Alliums are known for their therapeutic potential since antiquity. Alliums contain diverse bioactive compounds such as, sulfur-containing compounds (allicin, diallyl sulfides), flavonoids, and saponins. These compounds have demonstrated a wide range of pharmacological actions, including antioxidant, anticancer, anti-inflammatory, antimicrobial, neuroprotective, cardioprotective activities and treatment of metabolic disorders such as diabetes and hyperlipidemia. Despite encouraging preclinical results, translating these findings into clinical practice remains difficult, necessitating more rigorous human trials and molecular research. One of the major constrain in enhancing the therapeutic efficacy of these bioactive compound is to develop large-scale extraction techniques besides improving their stability, solubility, and bioavailability. The current scenario urges to focus research on optimizing the bioavailability of these compounds, evaluate their synergistic effects with existing therapies, as well as their long-term safety.This perspective article provides a comprehensive overview of the therapeutic potential of Allium spp. and suggests the key avenues for future research aiming at realising their full clinical potential.

    Keywords: Allium, bioactive compounds, Health benefits, Nutraceuticals, Therapeutic properties

    Received: 18 Sep 2024; Accepted: 31 Oct 2024.

    Copyright: © 2024 Gorrepati, Krishna, Singh, Shirsat, P. S. and Mahajan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Kalyani Gorrepati, ICAR-Directorate of Onion and Garlic Research, Rajgurunagar, Pune, India
    Soumia P. S., ICAR-Directorate of Onion and Garlic Research, Rajgurunagar, Pune, India

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.