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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1497529

The association of visceral fat metabolism score with hyperuricemia: evidence from NHANES 1999-2018

Provisionally accepted
Lin Xie Lin Xie 1Huali Qu Huali Qu 1Juan Li Juan Li 1Dandan Lai Dandan Lai 1Xushan Chen Xushan Chen 2Jiajia Xie Jiajia Xie 2*
  • 1 The seventh clinical medical college of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
  • 2 Shenzhen Bao’an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China

The final, formatted version of the article will be published soon.

    Despite substantial evidence that visceral obesity is an epidemiological risk factor for hyperuricemia (HUA), the evidence on the connection between the Metabolic Score for Visceral Fat (METS-VF) and HUA remains insufficient. This research concentrated on the potential role of METS-VF as a risk factor for HUA. Methods 8,659 participants from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 were enrolled in this study. Propensity score matching (PSM), multivariate logistic regression analysis, subgroup analysis, interaction test, and restricted cubic spline (RCS) analysis were implemented to identify the correlation between METS-VF and HUA.In the fully adjusted model, the results of the multiple logistic regression analysis indicated that METS-VF was related to an elevated prevalence of HUA (before PSM: odds ratio (OR) = 3.51 (2.88, 4.27), P < 0.001; after PSM: OR = 2.90 (3.09, 4.93), P < 0.001). In RCS analysis, a non-linear positive correlation was observed between METS-VF and the incidence of HUA. (before PSM: P-nonlinear < 0.001; after PSM: P-nonlinear = 0.0065) Subgroup analysis and interaction tests revealed that the impact of METS-VF on HUA was modified by both gender and ethnicity.There is a significant positive correlation between METS-VF and HUA in US adults. METS-VF could serve as a valuable metric for assessing the development and progression of HUA.

    Keywords: Hyperuricemia, visceral fat, Cross-sectional survey, Propensity score matching, NHANES

    Received: 17 Sep 2024; Accepted: 12 Dec 2024.

    Copyright: © 2024 Xie, Qu, Li, Lai, Chen and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiajia Xie, Shenzhen Bao’an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China

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