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REVIEW article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1497364

Exploring the Application of Dietary Antioxidant Index for Disease Risk Assessment: A Comprehensive Review

Provisionally accepted
Hossein Pourmontaseri Hossein Pourmontaseri 1Sina Bazmi Sina Bazmi 1Matin Sepehrinia Matin Sepehrinia 1Ayda Mostafavi Ayda Mostafavi 2Reza Arefnezhad Reza Arefnezhad 3*Reza Homayounfar Reza Homayounfar 4*Farhad Vahid Farhad Vahid 5
  • 1 Fasa University of Medical Sciences, Fasa, Iran
  • 2 Panjab University, Chandigarh, Chandigarh, India
  • 3 Shiraz University of Medical Sciences, Shiraz, Fars, Iran
  • 4 Shahid Beheshti University of Medical Sciences, Tehran, Tehran, Iran
  • 5 Luxembourg Institute of Health, Luxembourg, Luxembourg

The final, formatted version of the article will be published soon.

    Oxidative stress contributes to the development of cardiometabolic diseases and cancers. Numerous studies have highlighted the adverse effects of high reactive oxygen species (ROS) levels in the progression of chronic noncommunicable diseases and also during infections. On the other hand, antioxidants play a crucial role in preventing oxidative stress or postponing cell damage via the direct scavenging of free radicals or indirectly via the Keap1/Nrf2/ARE pathway, among others. Dietary antioxidants can be obtained from various sources, mainly through a plant-based diet, including fruits and vegetables. The dietary antioxidant index (DAI) has been developed to assess total antioxidant intake from diet. This review delineated the performance of DAI in the risk assessment of different diseases. It is suggested that a high DAI score prevents obesity-related diseases, including diabetes mellitus, hyperuricemia, dyslipidemia, and metabolic (dysfunction)-associated steatotic liver disease (MASLD). Additionally, DAI is negatively associated with Helicobacter pylori and Human papillomavirus infection, thus reducing the risk of gastric and cervical cancer. Also, a high intake of antioxidants prevents the development of osteoporosis, miscarriage, infertility, and mental illnesses. However, further prospective observations and clinical trials are warranted to confirm the application of DAI in preventing diseases that have been studied.

    Keywords: metabolic disease, Mental Disorders, Cardiovascular Diseases, Cancer, Osteoporosis, Infertility, Obesity

    Received: 19 Sep 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Pourmontaseri, Bazmi, Sepehrinia, Mostafavi, Arefnezhad, Homayounfar and Vahid. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Reza Arefnezhad, Shiraz University of Medical Sciences, Shiraz, 71348-14336, Fars, Iran
    Reza Homayounfar, Shahid Beheshti University of Medical Sciences, Tehran, 198396-3113, Tehran, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.