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REVIEW article

Front. Nutr.
Sec. Nutrition and Food Science Technology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1496706

Obstacles, Research Progress, and Prospects of Oral Delivery of Bioactive Peptides: A Comprehensive Review

Provisionally accepted
Xinyu Wang Xinyu Wang 1Zeyao Yang Zeyao Yang 1Wangang Zhang Wangang Zhang 2Lujuan Xing Lujuan Xing 2Ruiming Luo Ruiming Luo 1Songmin Cao Songmin Cao 1*
  • 1 Ningxia University, Yinchuan, China
  • 2 Nanjing Agricultural University, Nanjing, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Bioactive peptides hold significant potential for enhancing human health, however, their limited oral bioavailability poses a substantial barrier to their widespread use in the food and pharmaceutical industries. This article reviews the key factors influencing the absorption efficiency of oral bioactive peptides, including issues related to bitter taste perception, challenges in gastrointestinal environmental stability, and limitations in transmembrane transport. Furthermore, it highlights the latest technologies, such as osmotic technology, chemical modification, and advanced delivery systems, and discusses their advantages in enhancing the stability of bioactive peptides and facilitating intestinal absorption. In addition, the application and challenges of common delivery systems such as liposomes, emulsions, polymer nanoparticles, and hydrogels in oral bioactive peptide delivery are also discussed. This paper aims to provide a theoretical foundation for scientific research and practical applications of oral delivery of bioactive peptides, thereby promoting the further development of bioactive peptides in the context of human health.

    Keywords: Bioactive peptides1, oral administration2, Bioavailability3, oral delivery systems4, peptide transport5

    Received: 15 Sep 2024; Accepted: 23 Oct 2024.

    Copyright: © 2024 Wang, Yang, Zhang, Xing, Luo and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Songmin Cao, Ningxia University, Yinchuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.