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REVIEW article

Front. Nutr.
Sec. Nutrigenomics
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1495993
This article is part of the Research Topic The Application of Network Analysis in Ethnopharmacology and Food Nutrition Volume II View all articles

The Regulation Effects of Bioactive Polysaccharides on Intestinal Function and Bile Acids: Chemical Structures, Bioactivities and Mechanisms

Provisionally accepted
Anqi Wang Anqi Wang *Wugui Xiong Wugui Xiong Jing Li Jing Li Hu Yingfan Hu Yingfan Liang Zou Liang Zou Ying Liu Ying Liu
  • Chengdu University, Chengdu, China

The final, formatted version of the article will be published soon.

    Polysaccharides is one of important components of human diet carrying with a wide range of biological activities, especially for the activities in the improvement of inflammation of digestive system and metabolic diseases. Among all the reported bioactivities of polysaccharides, the regulation effects in intestinal function and bile acids in experiments are gradually attracting more and more researchers' attention. Bile acids, the main components of intestinal lipid digestive fluid, are also the key signal factors for metabolic homeostasis and impact on body health. Polysaccharides usually directly or indirectly interact with the gut and gut microbiota to participate in the regulation process of reabsorption, metabolism and excretion of bile acids in human, and thus exerting their intervention role for human diseases. In this paper, we comprehensively reviewed the effects of bioactive polysaccharides in regulation of intestinal function and bile acids. The chemical structures, bioactivities and potential mechanisms for their activities are also reviewed, which aims to provide a comprehensive reference for the future researches in the activities and mechanisms of polysaccharides, and to provide important strategies and thoughts for the development of bioactive polysaccharides for preventing inflammatory and metabolic diseases.

    Keywords: Polysaccharides, Bile acids, Metabolic Diseases, Inflammation, Gut Microbiota, Intestinal function

    Received: 13 Sep 2024; Accepted: 30 Oct 2024.

    Copyright: © 2024 Wang, Xiong, Li, Yingfan, Zou and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Anqi Wang, Chengdu University, Chengdu, China

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