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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1495792
This article is part of the Research Topic The Role of Foods, Diet, and Dietary Patterns in the Prevention and Management of Diabesity View all articles

Association between Cardiometabolic index and Frailty among patients with Diabetes Mellitus: a Cross-sectional study

Provisionally accepted
Yi Wei Yi Wei *Jiangyi Yu Jiangyi Yu *
  • Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, China

The final, formatted version of the article will be published soon.

    Background: Cardiometabolic index (CMI) is a novel marker that can assess metabolic status.Studies have found that people with diabetes mellitus (DM) are at high risk of developing frailty.However, there is a lack of evidence between CMI and the risk of frailty in patients with DM.Therefore, the aim of this study was to investigate the association between CMI and frailty in patients with DM.Methods：Weighted multivariate logistic regression was conducted in this study to explore the association between CMI and frailty status in patients with DM. In addition, subgroup analyses and interaction analyses were conducted to assess heterogeneity between different subgroups.Subsequently, restricted cubic spline (RCS) was also used to test for non-linear relationships.Results：This study ultimately included 2,761 patients with DM. Weighted multivariate logistic regression showed that, after adjusting all covariates, an increase in the level of CMI was associated with an increased risk of being in a frailty status in patients with DM (OR=1.12, 95% CI=1.04-1.22, P=0.005). Dividing CMI into tertiles, the risk of frailty in patients in the highest tertile (Q3) was higher than that of patients in Q1 (OR=1.56, 95% CI=1.18-2.07, P=0.002). The non-linear relationship between CMI and the risk of frailty in DM patients was further confirmed by RCS analysis.Conclusion：This study found that the higher the CMI, the higher the risk of frailty in DM patients.Maintaining a healthy low-fat dietary pattern and properly controlling blood lipid levels may reduce the risk of frailty in people with DM.

    Keywords: Diabetes Mellitus, Frailty, NHANES, Cross-sectional study, Cardiometabolic index

    Received: 13 Sep 2024; Accepted: 13 Nov 2024.

    Copyright: © 2024 Wei and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yi Wei, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, China
    Jiangyi Yu, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.