Skip to main content

SYSTEMATIC REVIEW article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1488054

Efficacy and safety of post-discharge oral nutritional supplements (ONS) for patients with gastric cancer undergoing gastrectomy: a meta-analysis of randomized controlled trials

Provisionally accepted
Qiuman Liang Qiuman Liang 1Siyi Wang Siyi Wang 2*Beibei Wang Beibei Wang 3*Yanyan Hong Yanyan Hong 1*
  • 1 Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Jiangsu Nanjing 210022, China, Nanjing, China
  • 2 School of Nursing, Nanjing University of Chinese Medicine, Jiangsu Nanjing 210023, China, Nanjing, China
  • 3 School of Elderly Care Services and Management, Nanjing University of Chinese Medicine, Jiangsu Nanjing 210023, China, Nanjing, China

The final, formatted version of the article will be published soon.

    Abstract Objectives: To report the first and largest systematic review and meta-analysis of randomized controlled trials (RCT) to evaluated the efficacy and safety of post-discharge oral nutritional supplements (ONS) for patients with gastric cancer undergoing gastrectomy. Design: Systematic review and meta-analysis. Eligibility criteria for selecting studies: RCT which evaluated the efficacy and/or safety of post-discharge ONS for patients with gastric cancer undergoing gastrectomy. Data sources: We conducted a systematic literature retrieval via PubMed, Embase, Web of Science, and Cochrane until April, 2023 for relevant RCTs. Data analysis: outcomes of meta-analysis included absolute change of body weight, % change of body weight, absolute change of body composition, absolute change of laboratory parameters and adverse events. All the relevant data were analysed by Review Manager 5.4.1 and Stata 15.1. Results: 5 RCTs including 1586 patients (804 in ONS group versus 782 in control group) were included for meta-analysis. The two groups were comparable in age, gender (male), weight at baseline, BMI at baseline, albumin at baseline, and hemoglobin at baseline. Meta-analysis revealed a significant lower absolute body weight loss (WMD: 0.75; 95% CI: 0.11, 1.40; P = 0.02) and % body weight loss (WMD: 1.15; 95% CI: 0.20, 2.11; P = 0.02) in the ONS group compared with the control (regular diet/dietary advice) group. Moreover, this study did not observe a significant difference between the two groups for adverse events rate (RR: 1.11; 95% CI: 0.81, 1.53; P = 0.52). Conclusions: ONS was significantly effective and safe in improving postoperative weight loss for patients with gastric cancer undergoing gastrectomy. PROSPERO registration number: CRD42023414678.

    Keywords: gastric cancer, Gastrectomy, Meta-analysis, ONS, Systematic review

    Received: 29 Aug 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Liang, Wang, Wang and Hong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Siyi Wang, School of Nursing, Nanjing University of Chinese Medicine, Jiangsu Nanjing 210023, China, Nanjing, China
    Beibei Wang, School of Elderly Care Services and Management, Nanjing University of Chinese Medicine, Jiangsu Nanjing 210023, China, Nanjing, China
    Yanyan Hong, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Jiangsu Nanjing 210022, China, Nanjing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.