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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1487730

Assessment of the maternal key micronutrient supply and its correlation with cord blood parameters in twin pregnancies

Provisionally accepted
Magdalena Zgliczynska Magdalena Zgliczynska 1*Magdalena Ostrowska Magdalena Ostrowska 2Kinga Zebrowska Kinga Zebrowska 1Iga Rzucidlo-Szymanska Iga Rzucidlo-Szymanska 1Iwona Szymusik Iwona Szymusik 1Konrad Kowalski Konrad Kowalski 3Katarzyna Kosinska-Kaczynska Katarzyna Kosinska-Kaczynska 1
  • 1 Department of Obstetrics, Perinatology and Neonatology, Centre of Postgraduate Medical Education, Warsaw, Poland
  • 2 Department of Endocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland
  • 3 Masdiag Sp. z o.o., Stefana Żeromskiego, Warsaw, Poland

The final, formatted version of the article will be published soon.

    Background: Multiple pregnancy constitutes a large metabolic expense. Therefore, so women with twin pregnancies and neonates born as twins might be at a risk for micronutrient deficiencies. Therefore, the aim of the study was to assess the supplementation used and supply with key micronutrients: iron, vitamin B12, folic acid and vitamin D in women with twin pregnancies and the correlations with cord blood indicators.Methods: Maternal and cord blood samples were collected from 51 patients with twin pregnancies and 102 newborns born from those pregnancies between October 2020 and September 2023. Ferritin, vitamin B12, folic acid and vitamin D metabolite concentrations were measured. Additionally, the patients completed a questionnaire regarding pre-and intragestational supplementation before and during pregnancy.Results: Iron, vitamin B12, and vitamin D deficiency were diagnosed in 20.8%, 13.7% and 12.5% of women with twin pregnancies, respectively. No maternal folate deficiency was identified. Positive weak to moderate correlations were demonstrated between the concentrations of all studied indicators in the maternal and cord blood were found.Pregestational folic acid and vitamin D supplementation was associated with higher cord blood levels of folic acid and 3-epi-25(OH)D3, respectively. 25(OH)D3 and total 25(OH)D concentrations were higher in newborns whose mothers had supplemented vitamin D during pregnancy.The problem of iron, vitamin B12 and vitamin D deficiencies in twin pregnancies is still presentvalid. Pre-and intragestational supplementation, as well as maternal micronutrient supply affect the cord blood composition inof twins.

    Keywords: Twin pregnancy, cord blood, micronutrient, Iron, Vitamin B12, Folic Acid, Vitamin D

    Received: 28 Aug 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Zgliczynska, Ostrowska, Zebrowska, Rzucidlo-Szymanska, Szymusik, Kowalski and Kosinska-Kaczynska. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Magdalena Zgliczynska, Department of Obstetrics, Perinatology and Neonatology, Centre of Postgraduate Medical Education, Warsaw, Poland

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