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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1486958

Ovarian reserve modulates the impact of vitamin D deficiency on assisted reproductive outcomes in patients undergoing controlled ovarian hyperstimulation

Provisionally accepted
Lina He Lina He 1Qing Xu Qing Xu 1Li Hao Li Hao 1Xu Ran Xu Ran 1Yamin Qiu Yamin Qiu 1Jie Lin Jie Lin 1Wei Chen Wei Chen 2*
  • 1 Zigong Hospital of Women and Children Health Care, Zigong, Sichuan Province, China
  • 2 Zigong Fourth People's Hospital, Zigong, China

The final, formatted version of the article will be published soon.

    Objective: The association between vitamin D deficiency and ovarian reserve-specific outcomes of assisted reproductive technology (ART) remains uncertain. This study aimed to investigate the role of ovarian reserve in the association between basal serum vitamin D levels and ART outcomes in patients undergoing controlled ovarian hyperstimulation (COH).Methods: A total of 1,333 infertile women undergoing COH cycles were retrospectively analyzed. Patients were divided into a vitamin D deficiency group (serum vitamin D <20 ng/mL) and a normal vitamin D group. Univariate and multivariate logistic regression analysis was performed to estimate the relationship between vitamin D deficiency and pregnancy outcomes including biochemical pregnancy rate, clinical pregnancy rate, miscarriage rate, and live birth rate in the overall cohort and in subgroups with diminished ovarian reserve (DOR) or polycystic ovary syndrome (PCOS).Results: In the entire participants' cohort, no correlation between vitamin D deficiency and pregnancy results was observed (p>0.05). However, in the DOR subgroup, vitamin D deficiency was associated with a lower biochemical pregnancy rate (adjusted OR 0.27; 95% CI 0.08-0.90; p<0.01) and clinical pregnancy rate (adjusted OR 0.36; 95% CI 0.14-0.90; p<0.01). No significant differences were observed in pregnancy outcomes among patients with PCOS (p > 0.05).Conclusions: Vitamin D deficiency does not affect pregnancy outcomes in the overall patient population, but it may negatively impact women with DOR to poor pregnancy outcomes. Further studies are needed to clarify the mechanisms involved and the potential use of vitamin D screening and supplementation in specific populations.

    Keywords: Vitamin D, Controlled ovarian hyperstimulation, in vitro fertilization, Assisted reproductive, diminished ovarian reserve

    Received: 27 Aug 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 He, Xu, Hao, Ran, Qiu, Lin and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wei Chen, Zigong Fourth People's Hospital, Zigong, China

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