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REVIEW article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1485632

Intermittent Fasting, Fatty Acid Metabolism Reprogramming, and Neuroimmuno Microenvironment: Mechanisms and Application Prospects

Provisionally accepted
Yu He Yu He 1,2Junyu Wang Junyu Wang 1,3Yinuo Zhao Yinuo Zhao 1,3*Anren Zhang Anren Zhang 1,3*Nianyi Sun Nianyi Sun 1,3*
  • 1 Shanghai Fourth People's Hospital, Shanghai, China
  • 2 Department of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China
  • 3 School of Medicine, Tongji University, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    Intermittent fasting (IF) has demonstrated extensive health benefits through the regulation of fatty acid metabolism and modulation of the neuroimmune microenvironment, primarily via the activation of key signaling pathways such as AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1). IF not only facilitates fatty acid oxidation and improves metabolic health, but also enhances mitochondrial function, mitigates oxidative stress, promotes autophagy, and inhibits apoptosis and ferroptosis. These mechanisms contribute to its substantial preventive and therapeutic potential in various conditions, including neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, autoimmune diseases, and neurotraumatic conditions. While supportive evidence has been obtained from animal models and preliminary clinical studies, further large-scale, long-term randomized controlled trials are imperative to establish its safety and evaluate its clinical efficacy comprehensively.

    Keywords: intermittent fasting, fatty acid metabolism, Neuroimmuno Microenvironment, AMPK, SIRT1, Ketone Bodies, Autophagy

    Received: 24 Aug 2024; Accepted: 15 Oct 2024.

    Copyright: © 2024 He, Wang, Zhao, Zhang and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yinuo Zhao, Shanghai Fourth People's Hospital, Shanghai, China
    Anren Zhang, Shanghai Fourth People's Hospital, Shanghai, China
    Nianyi Sun, Shanghai Fourth People's Hospital, Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.