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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1485428
This article is part of the Research Topic Nutrients, Stress Response, and Human Health View all 7 articles

Association between oxidative balance score and serum cobalt level in population with metal implants: a cross-sectional study from NHANES 2015-2020

Provisionally accepted
Wenxiu Yuan Wenxiu Yuan 1Jing Chen Jing Chen 2Jun Sun Jun Sun 3Chenyang Song Chenyang Song 4Zhi Chen Zhi Chen 4*
  • 1 Fujian Medical University, Fuzhou, Fujian Province, China
  • 2 Fujian Provincial Hospital, Fuzhou, Fujian Province, China
  • 3 The Tranditional Chinese Medical Hospital of Zhaotong, Zhaotong, Yunnan, China
  • 4 Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China

The final, formatted version of the article will be published soon.

    Background: Growing evidence indicates that metal implants influence the body's oxidative stress status, which in turn affects the degradation and stability of metal implants.The oxidative balance score (OBS) is a composite indicator, reflecting the overall oxidative balance of pro-and antioxidants of the human body. However, the associations between OBS and the level of metal ions on the population with metal implants remain to be elucidated.We conducted a cross-sectional study using data from 2015 to 2020 National Health and Nutrition Examination Survey (NHANES). Dietary and lifestyle factors closely associated with oxidative stress were quantified to calculate the OBS. Weighted multivariate logistic regression and smooth curve fittings were performed to examine the relationship between OBS and serum cobalt levels. Subgroup analyses were stratified by age and gender. In cases where nonlinearity was detected, threshold effects were assessed using a two-piecewise linear regression model.A total of 549 participants were included in this analysis. The dietary OBS was negatively associated with serum cobalt level in fully adjusted model (β=-0.179, 95%CI: -0.358 to -0.001, P: 0.04918). Stratified by age and gender, negative correlation of OBS and dietary OBS with serum cobalt level was observed only in men and age over 70 years participants. Threshold effect analysis showed linear relationships between OBS, dietary OBS and cobalt level in males. There were nonlinear relationships between OBS, dietary OBS and cobalt level in age over 70 years participants, with inflection points identified at 16.3 and 8.7 for OBS and dietary OBS, respectively.Conclusions: Our study confirms the inverse relationships between oxidative stress and serum cobalt level in individuals with metal implants, highlighting the significance of optimizing OBS to mitigate the risk of metal ion toxicity. These findings emphasize the importance of maintaining an antioxidant diet and lifestyle, particularly as they offer greater protective effect for males and the elderly population.

    Keywords: Metal implant, Oxidative balance score, Cobalt, NHANES, dietary

    Received: 23 Aug 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Yuan, Chen, Sun, Song and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhi Chen, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian Province, China

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