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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1485399

The Dietary Inflammatory Index and Asthma Prevalence: A Cross-Sectional Analysis from NHANES

Provisionally accepted
Chuansen Lu Chuansen Lu 1Yike Zhu Yike Zhu 2*
  • 1 Department of Neurology, Hainan General Hospital, Haikou, Hainan Province, China
  • 2 Department of Respiratory and Critical Care Medicine, Hainan General Hospital, Haikou, Hainan Province, China

The final, formatted version of the article will be published soon.

    Background: Inflammation is a key factor in the development of asthma, and diet significantly influences inflammatory responses. This study examines the relationship between the Dietary Inflammatory Index (DII) and asthma prevalence.We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. Demographic details, anthropometric measurements, dietary habits, lifestyle factors, and asthma status were recorded for all participants. Multivariable logistic regression was utilized to assess the link relationship between DII and asthma prevalence. Additionally, restricted cubic spline (RCS) analysis was employed to explore the nonlinearity and dose-response relationship between the DII and asthma risk. Subgroup analyses were stratified by gender, age, race, body mass index (BMI), poverty income ratio (PIR), education, smoking status, alcohol use, and family medical history were performed to dissect the association of the between DII and asthma across diverse populations.The analysis included 37,283 adults from NHANES. After adjusting for potential confounders in the multivariable logistic regression model, a significant positive association was identified between DII and asthma (OR, 95% CI: 1.05, 1.02-1.09, per 1 SD increase). The RCS analysis revealed a nonlinear association (P for nonlinearity = 0.0026), with an inflection point at 1.366, beyond which an increase in DII was significantly correlated associated with asthma risk. Furthermore, the stratified analyses indicated a positive correlation association between DII and asthma in the majority of subgroups.The findings underscore a significant and nonlinear association between DII and asthma. To enhance asthma prevention and management, greater emphasis should be placed on modulating dietary-induced inflammation.

    Keywords: Asthma, Dietary inflammatory index, NHANES, Cross-sectional, Inflammation

    Received: 23 Aug 2024; Accepted: 08 Nov 2024.

    Copyright: © 2024 Lu and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yike Zhu, Department of Respiratory and Critical Care Medicine, Hainan General Hospital, Haikou, 570311, Hainan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.