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REVIEW article

Front. Nutr.
Sec. Food Chemistry
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1484865
This article is part of the Research Topic Plant and Fungal Metabolites: Innovations in Special Dietary Foods and Disease Prevention View all 3 articles

Extraction, purification, structural characterization, bioactivities, modifications and structure-activity relationship of polysaccharides from Ophiopogon japonicus: A review

Provisionally accepted
Yiqiang Zhang Yiqiang Zhang 1Bo Chen Bo Chen 2Hua Zhang Hua Zhang 3Juan Zhang Juan Zhang 1Juan Xue Juan Xue 3,4*
  • 1 Jingmen City Hospital of Traditional Chinese Medicine, Jingmen, China
  • 2 Second Hospital of Yichang, Yichang, Hubei Province, China
  • 3 Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Wuhan, Hubei Province, China
  • 4 Hubei University of Chinese Medicine, Wuhan, Hubei Province, China

The final, formatted version of the article will be published soon.

    Ophiopogon japonicus (Thunb.) Ker Gawl., is a traditional Chinese medicine (TCM) with a history of thousands of years. O. japonicus polysaccharides (OJPs), as one of the main active ingredient, are a kind of representative pharmacological bioactive macromolecules and mainly composed of Glc and Fru with molecular weight between 2.48 kDa to 325 kDa. OJPs have a variety of biological activities, such as hypoglycemic, cardioprotective, immunomodulatory, improvement of obesity, and renal protective activity. In this review, the extraction, purification and structural characterization of OJPs were systematically reviewed, and its biological function, molecular mechanism and structure-activity relationship were analyzed.Additionally, this review summarized and found that structural modifications such as liposome modification, sulfation modification, and polyethylene glycol modification have improved the pharmacological activity and bioavailability of OJPs. Overall, this work will help to better understand OJPs and provide a theoretical review of their further development and utilization in the field of medicine and health food.

    Keywords: Ophiopogon japonicus, Polysaccharides, extraction methods, Structural characterization; Biological activities, structure-activity relationship

    Received: 22 Aug 2024; Accepted: 09 Oct 2024.

    Copyright: © 2024 Zhang, Chen, Zhang, Zhang and Xue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Juan Xue, Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Wuhan, 430015, Hubei Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.