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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1484756

Higher oxidative balance score is associated with lower female infertility: A cross-sectional study

Provisionally accepted
Xiong Lei Xiong Lei 1Xiling Liu Xiling Liu 1*Chunchun Yu Chunchun Yu 1*Lijing Xia Lijing Xia 1*Liwen Zhou Liwen Zhou 1*Can Yao Can Yao 2*Zhixiao Xu Zhixiao Xu 1*
  • 1 Wenzhou Medical University, Wenzhou, China
  • 2 Fudan University, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    Background: An imbalance of the pro-oxidant and anti-oxidant profiles in the body contributes to the development of diseases, including female infertility.In this study, we performed a secondary analysis of the National Health and Nutrition Examination Survey and calculated the values of oxidative balance score (OBS). A weighted logistic regression model was used to explore the potential relationship between OBS (continuous factor and quartile set) and female infertility, and the P for trend was calculated. Subgroup analyses were also carried out further to explore the association between OBS and female infertility, and the P for interactions were obtained.Results: There were 1,626 females (aged 18 to 45) were included in the study, including 198 with infertility and a prevalence of approximately 13.28%. Multifactorial logistic regression showed a 5% decrease in infertility for each unit increased in OBS (OR, 0.95; 95% CI, 0.92 to 0.98). When OBS was used as a categorical variable, female infertility decreased by 60% in the highest OBS group compared with the lowest OBS group (OR, 0.40; 95%CI, 0.21 to 0.74). In addition, subgroup analyses showed that the negative association between OBS and infertility was significant in the nonchronic-disease (hypertension and diabetes) population, less than high school educational background, poverty to income ratio (1 to 3), and those more than 30 years of age.Higher OBS was negatively associated with female infertility. Further prospective studies are needed to determine causality and to provide new perspectives on female infertility in the context of diet and lifestyle.

    Keywords: Female infertility, Oxidative balance score, NHANES, dietary, lifestyle

    Received: 22 Aug 2024; Accepted: 20 Nov 2024.

    Copyright: © 2024 Lei, Liu, Yu, Xia, Zhou, Yao and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiling Liu, Wenzhou Medical University, Wenzhou, China
    Chunchun Yu, Wenzhou Medical University, Wenzhou, China
    Lijing Xia, Wenzhou Medical University, Wenzhou, China
    Liwen Zhou, Wenzhou Medical University, Wenzhou, China
    Can Yao, Fudan University, Shanghai, 200433, Shanghai Municipality, China
    Zhixiao Xu, Wenzhou Medical University, Wenzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.