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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1484017
This article is part of the Research Topic Assessment of Nutritional Status in Chronic Diseases View all 6 articles

Nutritional Assessment of Chinese Gynecologic Cancer Survivors with Post-Surgical Lower Limb Lymphedema: A Cross-Sectional Study

Provisionally accepted
Chunshui He Chunshui He 1*Xiaoling Zhun Xiaoling Zhun 1Xinjun Liu Xinjun Liu 1Jinbo Tian Jinbo Tian 1Shan Huang Shan Huang 2
  • 1 Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
  • 2 Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Objective: This study aims to evaluate the nutritional status of Chinese gynecologic cancer survivors with post-surgical lower limb lymphedema (LLL) by analyzing serum albumin levels and the prognostic nutritional index (PNI).: A retrospective cross-sectional study was conducted at two Chinese medical centers. The cohort comprised 155 gynecologic cancer survivors who developed symptomatic unilateral LLL post-surgery, during the period from September 2021 to June 2024. Nutritional status was assessed by measuring serum albumin and PNI. Statistical analysis was performed using univariate and multivariate logistic regression models to identify factors associated with low serum albumin and PNI. Univariate and multivariate logistic regression analyses were performed to identify factors associated with low serum albumin and PNI.The mean age of the cohort was 55.47 ± 10.56 years, and the median total survival time was 72.0 months (36.5, 111.5 months). The prevalence of low serum albumin (<40 g/L) was 40.0%, and low PNI (<45) was 80.6%. Significant associations were found between low hemoglobin levels and both low serum albumin (OR = 1.05, 95% CI: 1.02-1.08, p<0.001) and low PNI (OR = 1.09, 95% CI: 1.04-1.13, p<0.001). Advanced International Society of Lymphology stage 3 was also associated with low albumin (OR = 0.18, 95% CI: 0.03-0.99, p<0.05).The study highlights a significant prevalence of high risk of malnutrition among Chinese gynecologic cancer survivors with LLL, underscoring the need for regular nutritional assessments and interventions.

    Keywords: Gynecologic cancers, Lower limb lymphedema, Nutritional Status, Serum Albumin, Prognostic nutritional index

    Received: 21 Aug 2024; Accepted: 08 Oct 2024.

    Copyright: © 2024 He, Zhun, Liu, Tian and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chunshui He, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.