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REVIEW article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1483515

Association between dietary vitamin B6 intake and constipation: a population-based study

Provisionally accepted
Xuefeng Liu Xuefeng Liu 1,2Yuedong Liu Yuedong Liu 1,2*Shu Yuping Shu Yuping 3Hongwu Tao Hongwu Tao 1*Zewei Sheng Zewei Sheng 1,2*Yuyu Peng Yuyu Peng 1*Meiqi Cai Meiqi Cai 1,2*Xiaoming Zhang Xiaoming Zhang 2*Weiru Lan Weiru Lan 2*
  • 1 Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
  • 2 Third Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, China
  • 3 Fujian Provincial People's Hospital, Fuzhou, Fujian Province, China

The final, formatted version of the article will be published soon.

    Background: Numerous studies have suggested a link between dietary micronutrient intake and the onset of constipation. Nevertheless, there hasn't been much research done on the potential relationship between vitamin B6 and constipation. The purpose of this study was to determine whether dietary vitamin B6 consumption and chronic constipation are related among adult participants in the National Health and Nutrition Examination Survey (NHANES). Method: The study made use of information from the 2009–2010 NHANES health and nutrition survey. Respondents' dietary information was gathered using 24-hour dietary recalls. A range of statistical techniques, including as interaction tests, subgroup analyses, and curve fitting analyses, were used to examine the connection between dietary vitamin B6 intake and chronic constipation. Result: This study included 3,643 patients, with 270 (7.41%) diagnosed with persistent constipation. A fully adjusted multiple logistic regression analysis found that increasing dietary vitamin B6 consumption (OR=0.78, 95% CI: 0.68-0.89) was linked to a lower incidence of constipation, with significance at p<0.05. After accounting for numerous factors, the odds ratio and 95% confidence interval for the third tertile compared to the reference group (first tertile) were 0.85 (0.74, 0.98), with statistical significance at p<0.05. Furthermore, subgroup analysis and interaction assessments revealed a substantial negative link between vitamin B6 intake and the occurrence of constipation, particularly in males and alcohol drinkers (all P values were less than 0.05). Conclusion: This study found an inverse connection between vitamin B6 consumption and the prevalence of persistent constipation. More extensive prospective trials are needed to fully examine the long-term influence of vitamin B6 on persistent constipation.

    Keywords: Vitamin B6, Constipation, NHANES, dietary intake, Population-based Study

    Received: 20 Aug 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Liu, Liu, Yuping, Tao, Sheng, Peng, Cai, Zhang and Lan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuedong Liu, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
    Hongwu Tao, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
    Zewei Sheng, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
    Yuyu Peng, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
    Meiqi Cai, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
    Xiaoming Zhang, Third Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, China
    Weiru Lan, Third Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.