Skip to main content

ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1477403

Association Between Micronutrients and Myopia in American Adolescents: Evidence from the 2003-2006 National Health and Nutrition Examination Survey

Provisionally accepted
Kunhong Xiao Kunhong Xiao 1Ruiye Chen Ruiye Chen 2*Rong Lin Rong Lin 3*Wenyi Hu Wenyi Hu 2Jiahao Liu Jiahao Liu 2Mayinuer Yusufu Mayinuer Yusufu 2*Yan Huang Yan Huang 1*Li Li Li Li 4*
  • 1 Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China
  • 2 The Royal Victorian Eye & Ear Hospital, Melbourne, Victoria, Australia
  • 3 West China Xiamen Hospital of Sichuan University, Xiamen, Fujian Province, China
  • 4 Fujian Provincial Hospital, Fuzhou, Fujian Province, China

The final, formatted version of the article will be published soon.

    Purpose: To investigate the associations between circulating micronutrients (vitamins A, C, D, E, and carotenoids) and the risk of myopia. Methods: A total of 1,620 adolescents from the 2003-2006 National Health and Nutrition Examination Survey (NHANES) were included. Logistic regression was used to analyze the associations of micronutrients with myopia and high myopia. Restricted cubic spline analysis was employed to assess the potential nonlinear relationships. Results: Among the 1,620 adolescents, 549 were diagnosed with myopia. After adjusting for multiple covariates, only cis-β-carotene was significantly associated with the risk of myopia (OR 1.19, 95% CI 1.03-1.39) and high myopia (OR 1.44, 95% CI 1.03-2.03). No significant associations were found between vitamins A, D, E, C, α-carotene, trans-β-carotene, lutein zeaxanthin, and myopia. No nonlinear relationships were observed between any of the micronutrients and myopia. Conclusion: Cis-β-carotene is significantly associated with an increased risk of myopia and high myopia. Further research is needed to understand the underlying mechanisms and potential impact of cis-β-carotene on ocular health

    Keywords: Micronutrients, Myopia, NHANES, Cis-β-carotene, Diet

    Received: 14 Aug 2024; Accepted: 17 Sep 2024.

    Copyright: © 2024 Xiao, Chen, Lin, Hu, Liu, Yusufu, Huang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Ruiye Chen, The Royal Victorian Eye & Ear Hospital, Melbourne, 3002, Victoria, Australia
    Rong Lin, West China Xiamen Hospital of Sichuan University, Xiamen, Fujian Province, China
    Mayinuer Yusufu, The Royal Victorian Eye & Ear Hospital, Melbourne, 3002, Victoria, Australia
    Yan Huang, Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China
    Li Li, Fujian Provincial Hospital, Fuzhou, 350001, Fujian Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.