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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1472002

Associations between dietary coenzyme Q10 intake and lipid profiles in adults: A national cross-sectional study

Provisionally accepted
Mingzhu Zhao Mingzhu Zhao 1,2,3Zezhong Tian Zezhong Tian 1,2,3Dan Zhao Dan Zhao 1,2,3Huiying Kuang Huiying Kuang 1,2,3Ying Liang Ying Liang 1,2,3Zhihao Liu Zhihao Liu 1,2,3Yixuan Xu Yixuan Xu 1,2,3Shanshan Hou Shanshan Hou 1,2,3Zepei Zhong Zepei Zhong 1,2,3Yan Yang Yan Yang 1,2,3*
  • 1 School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China
  • 2 Guangdong Engineering Technology Center of Nutrition Transformation, Sun Yat-sen University, Shenzhen, China
  • 3 Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Sun Yat-sen University, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Objective: This study aimed to determine the average intake of CoQ10 from dietary sources and explore the dose-response relationships between the dietary-derived CoQ10 intake and lipid profiles. Methods: We performed a cross-sectional study based on the China Health and Nutrition Survey, which included 7,938 adults. The dietary intake assessment used three consecutive 24-hour recalls combined with a household inventory. Serum was used for lipid profiling. Results: The average dietary-derived CoQ10 intake was 5.4 mg/day in Chinese adults. The dietary CoQ10 intake of the highest quartile (Q4 ≥ 6.96 mg/day) was negatively associated with total cholesterol (TC) [-0.12 (-0.19, -0.06) mmol/L], low-density lipoprotein cholesterol (LDL-C) [-0.17 (-0.23, -0.10) mmol/L], and non-high-density lipoprotein cholesterol (non-HDL-C) [-0.12 (-0.18, -0.05) mmol/L], while positively associated with apolipoprotein A-1 (ApoA1) [0.10 (0.08, 0.13) g/L] and triglycerides (TG) [0.14 (0.05, 0.23) mmol/L], compared to the lowest quartile (Q1 < 1.88 mg/day). Besides, dietary CoQ10 intake showed nonlinear dose-response associations with the above lipid variables (all P nonlinear < 0.05). Conclusions: Dietary-derived CoQ10 intake may be associated with some lipid profiles, such as TG, ApoA1, TC, LDL-C, and non-HDL-C. However, CoQ10 from dietary sources may not be a good choice for individuals who need to CoQ10 supplement.

    Keywords: dietary coenzyme Q10, Lipid profiles, Dose-response relationship, Cross-sectional study, Chinese adults

    Received: 28 Jul 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Zhao, Tian, Zhao, Kuang, Liang, Liu, Xu, Hou, Zhong and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yan Yang, School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.