Skip to main content

ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1470833

CDAI in the association of eczema with depression symptoms

Provisionally accepted
Tian Zhang Tian Zhang Ruohua Zhang Ruohua Zhang Ting Song Ting Song Fang Chen Fang Chen Yuegang Wei Yuegang Wei *
  • Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, China

The final, formatted version of the article will be published soon.

    The study aims to explore the associations of eczema, Composite Dietary Antioxidant Index (CDAI), with depression symptoms in adults based on the National Health and Nutrition Examination Surveys (NHANES) database.In total, 3402 participant data were extracted from the NHANES 2005-2006. The relationship between eczema, CDAI, and depression symptoms was explored by utilizing weighted univariate and multivariate logistic regression models, presenting as odds ratios (ORs) and 95% confidence intervals (CIs). The additive interaction between eczema, CDAI, and depression symptoms was measured by relative excess risk due to interaction (RERI) and the attributable proportion of interaction (AP). Subsequently, the associations of eczema, CDAI, with depression were also explored in different gender, body mass index (BMI), and smoking subgroups.Results: Of the 3402 participants included, the mean age was 46.76 (0.83) years old, and 174 (5.11%) participants had depression symptoms. In the adjusted model, both eczema (OR=3.60, 95%CI: 2.39-5.40) and CDAI (OR=1.97, 95%CI: 1.19-3.27) were associated with a higher prevalence of depression symptoms. Compared to the participants with high CDAI and no eczema, those participants with low CDAI (eczema: OR=7.30, 95%CI: 4.73-11.26; non-eczema: OR=1.84, 95%CI: 1.06-3.19) have higher odds of depression symptoms, no matter have eczema or not. When under low CDAI levels, eczema was associated with increased odds of depression symptoms (OR=3.76, 95%CI: 2.34-6.03). When under low CDAI level, eczema was also related to elevated odds of depression symptoms in those males, females, BMI <25, BMI ≥25, non-CDAI in the association of eczema with depression symptoms 4 smoking, and smoking.CDAI could modulate the association of eczema with depression symptoms in adults.

    Keywords: Composite Dietary Antioxidant Index, Eczema, Depression, moderating, NHANES (National Health and Nutrition Examination Survey)

    Received: 26 Jul 2024; Accepted: 12 Nov 2024.

    Copyright: © 2024 Zhang, Zhang, Song, Chen and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yuegang Wei, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.