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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrigenomics
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1467686

The association of dietary insulinemic indices with PI3K, PTEN, and Akt gene expressions in visceral and subcutaneous adipose tissues among individuals undergoing abdominal surgery

Provisionally accepted
Hamid Ahmadirad Hamid Ahmadirad 1Farshad Teymoori Farshad Teymoori 2Hossein Farhadnejad Hossein Farhadnejad 2Ghazaleh Shimi Ghazaleh Shimi 3Golaleh Asghari Golaleh Asghari 1Emad Yuzbashian Emad Yuzbashian 4Maryam Zarkesh Maryam Zarkesh 2*Parvin Mirmiran Parvin Mirmiran 1Alireza Khalaj Alireza Khalaj 5
  • 1 Department of Clinical Nutrition and Dietetics, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Alborz, Iran
  • 2 Research Institute for Endocrine Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 3 Shahid Beheshti University of Medical Sciences, Tehran, Tehran, Iran
  • 4 Department of Agricultural, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, Alberta, Canada
  • 5 Shahed University, Tehran, Tehran, Iran

The final, formatted version of the article will be published soon.

    Background/Objective: The current study investigates the association between dietary insulinemic indices and Akt, PTEN, and PI3K gene expressions in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) among individuals undergoing abdominal surgery. Material and Methods: This cross-sectional study was conducted on 176 individuals, aged 18-84 years, who had undergone abdominal surgery. The participants were classified based on body mass index(BMI) as normal(BMI<25 kg/m2 ), overweight(BMI=25-29.9 kg/m 2 ), and obese(BMI≥30 kg/m 2 ). The food frequency questionnaire was used to determine dietary glycemic and insulinemic indices. Real-time polymerase chain reaction was conducted for expression of PI3K, PTEN, and Akt genes. Results: In the final adjusted model, in normal-weight patients, there was an inverse relationship between the lifestyle with a higher insulinemic potential and the PI3K gene expression in VAT. Also, there was an inverse association between dietary insulin load and the Akt gene expression in VAT. However, a higher glycemic index was positively associated with the PTEN gene expression in VAT. In overweight patients, a high insulinemic potential of the diet was associated with higher PTEN gene expression in VAT. In obese individuals, there were positive associations between lifestyle index for insulin resistance and hyperinsulinemia and the PI3K gene expression in VAT. Moreover, the higher insulinemic potential of diet and lifestyle was positively related to a higher expression of the PTEN and Akt genes in VAT. Conclusions: Our findings revealed that high insulinemic lifestyles and dietary patterns may be related to the expression of PI3K, PTEN, and Akt in adipose tissues.

    Keywords: Insulinemic indices, Glycemic indices, PI3K, Pten, Akt, Gene Expression

    Received: 20 Jul 2024; Accepted: 10 Sep 2024.

    Copyright: © 2024 Ahmadirad, Teymoori, Farhadnejad, Shimi, Asghari, Yuzbashian, Zarkesh, Mirmiran and Khalaj. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Maryam Zarkesh, Research Institute for Endocrine Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.