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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Microbes
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1465940
This article is part of the Research Topic Advances in Sulfated Polysaccharides and Precision Nutrition View all articles

Effect of konjac glucomannan on the gut microbiota from hyperuricemia subjects in vitro: fermentation characteristic and inhibitory xanthine oxidase activity

Provisionally accepted
Jie Deng Jie Deng 1Kai Zhou Kai Zhou 2Caimin Feng Caimin Feng 1Yilu Bao Yilu Bao 1Zhiming Zhang Zhiming Zhang 1Wenfeng Luo Wenfeng Luo 3*Meiying Li Meiying Li 4*
  • 1 Shunde Vocational and Technical College, Foshan City, China
  • 2 Jiujiang University, Jiujiang, Jiangxi Province, China
  • 3 Guangzhou Panyu Central Hospital, Guangzhou, China
  • 4 Guangdong Provincial Key Lab of Food Safety and Quality, Guangzhou, China

The final, formatted version of the article will be published soon.

    The disorder of uric acid metabolism is closely associated with gut microbiota and short chain fatty acids (SCFAs) dysregulation, but the biological mechanism is unclear, limiting the development of uric acid-lowering active polysaccharides. Konjac glucomannan (KGM) could attenuate metabolic disturbance of uric acid and modulate the gut microbiota. However, the relationship between uric acid metabolism and gut microbiota is still unknown. Thus, the anaerobic fermentation in vitro was used to investigate the potential mechanism. The results showed that KGM could be utilized and degraded by gut microbiota from hyperuricemia (HUA) subjects and modulate the composition and structure of HUA gut microbiota toward to that of healthy group. Besides, KGM showed a superior modulated effect on HUA gut microbiota by increasing Megasphaera, Faecalibacterium, Lachnoclostridium, Lachnospiraceae, Anaerostipes and Ruminococcus and decreasing Butyricicoccus, Eisenbergiella and Enterococcus level. Furthermore, the fermentation solution of KGM showed inhibitory effect on xanthine oxidase (XOD) enzyme activity, which might be due to the metabolites such as SCFAs. Thus, KGM can be expected as novel prebiotics for treatment of HUA via modulating gut microbiota and promoting the production of SCFAs.

    Keywords: Konjac glucomannan, Short Chain Fatty Acids, Xanthine oxidase activity, Hyperuricemia, Uric Acid

    Received: 17 Jul 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Deng, Zhou, Feng, Bao, Zhang, Luo and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wenfeng Luo, Guangzhou Panyu Central Hospital, Guangzhou, China
    Meiying Li, Guangdong Provincial Key Lab of Food Safety and Quality, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.