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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrigenomics
Volume 11 - 2024 |
doi: 10.3389/fnut.2024.1464046
This article is part of the Research Topic The Intersection of Genes, Nutrition and Disease: A Nutritional Perspective from Mendelian Randomization to Disease Pathogenic Mechanisms View all 4 articles
Causal Relationship between Genetic-predicted Uric Acid and Cervical Cancer Risk: Evidence for Nutritional intervention on cervical cancer prevention
Provisionally accepted- 1 Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- 2 Hebi City People's Hospital, Hebi, China
- 3 Obstetrics and Gynecology Hospital, Fudan University, Shanghai, Shanghai Municipality, China
This study aimed to investigate the causal relationship between serum uric acid (SUA) levels and cervical cancer incidence, and to evaluate the potential role of nutritional interventions in cervical cancer prevention. We conducted a two-sample bidirectional Mendelian randomization (MR) analysis using genetic instruments from publicly available genome-wide association studies (GWASs) of individuals of predominantly European ancestry. Methods such as inverse-variance weighted, weighted-median, weighted model, and MR-Egger were applied. Sensitivity tests, including leave-one-out, MR-PRESSO, and Cochran's Q test, assessed heterogeneity and pleiotropy. Our findings revealed that a high SUA concentration significantly increased the risk of malignant cervical cancer: a 1 mg/ml increase in SUA was associated with a 71% higher risk (OR = 1.71, 95% CI=1.10-2.67; P=0.018). Stratification by histological type showed a significant causal effect on cervical adenocarcinoma risk (OR = 2.56, 95% CI=1.14-5.73; P=0.023). However, no clear evidence was found for a causal effect of cervical cancer on SUA levels. In conclusion, this study identified a causal relationship between elevated SUA levels and the risk of malignant cervical cancer, particularly cervical adenocarcinoma. These findings provide novel insights into the mechanisms of cervical carcinogenesis and suggest that managing SUA levels could be a potential strategy for cervical cancer prevention through dietary management.
Keywords: Uric Acid, cervical cancer, Mendelian randomization, Nutritional intervention, Dietary management, cancer prevention
Received: 13 Jul 2024; Accepted: 10 Sep 2024.
Copyright: © 2024 Cao, Wang, Liu, Zhang, Cai, Sun, Zhao and Yue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chunge Cao, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China
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