Skip to main content

SYSTEMATIC REVIEW article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1462931
This article is part of the Research Topic Nutrition and Metabolism in Cancer: Role in Prevention and Prognosis View all 15 articles

The association between empirical dietary inflammatory pattern and risk of cancer and cancer-specific mortality: a systematic review and meta-analysis of prospective cohort studies

Provisionally accepted
Fatemeh S. Hosseini Fatemeh S. Hosseini 1Ali Nikparast Ali Nikparast 2Elahe Etesami Elahe Etesami 1,3Fatemeh Javaheri-Tafti Fatemeh Javaheri-Tafti 2Golaleh Asghari Golaleh Asghari 2*
  • 1 Department of Nutrition, Science and Research Branch, Islamic Azad University of Medical Sciences, Tehran, Alborz, Iran
  • 2 Department of Clinical Nutrition and Dietetics, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 3 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Alborz, Iran

The final, formatted version of the article will be published soon.

    Background/Aim: Current evidence indicates a correlation between the inflammatory potential of diet and the risk of cancer and cancer-specific mortality. This study aimed to assess the association between empirical dietary inflammatory pattern (EDIP), which has recently been designed based on the inflammatory potential of the diet, and the risk of cancer and cancer-specific mortality. Methods: A literature search was conducted in PubMed/Medline, Scopus, and the Web of Sciences databases from their inception from January 2016 to March 2024. A random effects model was employed to calculate pooled Effect size (ES) and 95% confidence intervals (95% CI). The Cochran Q test and the I2 statistic were utilized to assess heterogeneity between studies. Results: From the initial 229 records, 24 prospective cohort studies with 2,683,350 participants and 37091 cancer incidence cases, as well as 20819 cancer-specific mortality, were included in our study. Pooled results demonstrated a significant association between higher adherence to EDIP and the risk of total cancer (ES:1.10;95%CI:1.05-1.15; I2=41.1), colorectal cancer (ES:1.19;95%CI:1.11-1.27; I2=41.1), and liver cancer (ES:1.48;95%CI:1.14-1.94; I2=36.9). However, no significant association between increased adherence to EDIP and the risk of ovarian or endometrial cancer was found. As well, greater adherence to EDIP was significantly associated with the risk of cancer-specific mortality (ES:1.18;95%CI:1.05-1.33; I2=45.4). Conclusion: Our results showed that a diet with higher inflammatory properties is associated with increased risk of cancer and cancer-specific mortality.

    Keywords: EDIP, Cancer, cancer-specific mortality, Meta-analaysis, Empirical dietary inflammatory pattern

    Received: 10 Jul 2024; Accepted: 01 Oct 2024.

    Copyright: © 2024 Hosseini, Nikparast, Etesami, Javaheri-Tafti and Asghari. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Golaleh Asghari, Department of Clinical Nutrition and Dietetics, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.