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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 |
doi: 10.3389/fnut.2024.1462300
Plasma Fatty Acid Levels and Risk of Non-Small Cell Lung Cancer: A Large-Scale Prospective Cohort Study
Provisionally accepted- 1 Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
- 2 Faculty of Medicine, University Hospital Leipzig, Leipzig, Lower Saxony, Germany
Background: Non-small cell lung cancer (NSCLC) ranks among the most prevalent and lethal malignancies globally. Fatty acids (FAs) play a significant role in diverse physiological and pathological mechanisms, yet their precise involvement in NSCLC remains poorly understood. Methods: This study utilized a large-scale prospective cohort of 249,132 participants, observed over an average of 12 years, to investigate the relationship between different FAs and NSCLC risk. Analytical approaches included Cox proportional hazards regression, Kaplan-Meier survival analysis, accelerated failure time (AFT) modeling, and restricted cubic spline (RCS) analysis. Results: During the follow-up period, 1,460 participants were diagnosed with NSCLC. Cox regression analysis demonstrated that elevated levels of docosahexaenoic acid (DHA), linoleic acid (LA), and omega-3 were inversely associated with NSCLC risk. Kaplan-Meier curves, along with AFT models, corroborated that elevated concentrations of DHA and LA significantly delayed NSCLC onset. Additionally, RCS analysis uncovered nuanced dose-response relationships between these FAs and NSCLC. Stratified analyses highlighted variability based on smoking status, gender, and body mass index subgroups.The concentration of specific FAs exhibits a significant association with NSCLC risk. These results offer a foundation for devising dietary FA composition adjustments aimed at reducing NSCLC risk.
Keywords: Non-small cell lung cancer, Fatty Acids, UK Biobank, prospective cohort study, cancer prevention
Received: 09 Jul 2024; Accepted: 02 Sep 2024.
Copyright: © 2024 Lin, Lin, Feng, Zheng, Yang and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shao-Fei Yuan, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China
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