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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1458484
This article is part of the Research Topic Dietary Modulation of Gut Microbiota-X axis View all articles

Inflammatory diet, Gut microbiota and Sensorineural hearing loss: a Crosssectional and Mendelian randomization study

Provisionally accepted
Yixuan Wang Yixuan Wang 1Jiayi Nie Jiayi Nie 2*Kaige Yan Kaige Yan 3*Jing Wang Jing Wang 1*Xin Wang Xin Wang 1*Yuxiang Zhao Yuxiang Zhao 1*
  • 1 Shaanxi Provincial People's Hospital, Xi'an, China
  • 2 Xi’an University of Technology, Xi‘an, China
  • 3 Northwest A&F University Herbarium, Yangling, China

The final, formatted version of the article will be published soon.

    Aims: Inflammatory diets can trigger chronic inflammation and affect gut microbiota. However, the relationship between dietary preferences and sensorineural hearing loss (SNHL) remains unclear. This study aims to elucidate the relationship between different dietary preferences and sensorineural deafness.Methods: The Dietary Inflammation Index (DII) and SNHL were defined by data from the National Health and Nutrition Examination Survey (NHANES), and exploring their relationship. Using Mendelian randomization (MR) to analyze the relationship between 34 dietary preferences, 211 gut microbiota, and SNHL. Results: Smooth curve fitting indicated that the risk of SNHL increased with increasing DII score when the DII score was greater than 5.15. MR results suggest that a diet including both oily and non-oily fish can substantially reduce the risk of SNHL. Additionally, six specific gut microbiota were found to have significant causal relationship with SNHL. Conclusion: An inflammatory diet may increase the risk of developing SNHL. The observed relationship between fish consumption, gut microbiota, and SNHL suggests the existence of a gut-inner ear axis.

    Keywords: inflammatory diet, Gut Microbiota, sensorineural hearing loss, NHANES, Mendelian randomization

    Received: 02 Jul 2024; Accepted: 01 Aug 2024.

    Copyright: © 2024 Wang, Nie, Yan, Wang, Wang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jiayi Nie, Xi’an University of Technology, Xi‘an, China
    Kaige Yan, Northwest A&F University Herbarium, Yangling, China
    Jing Wang, Shaanxi Provincial People's Hospital, Xi'an, China
    Xin Wang, Shaanxi Provincial People's Hospital, Xi'an, China
    Yuxiang Zhao, Shaanxi Provincial People's Hospital, Xi'an, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.