Skip to main content

ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1456502

Association between dietary folate intake and severe headache or migraine in adults: A cross-sectional study of the National Health and Nutrition Examination Survey

Provisionally accepted
Dehua Zhao Dehua Zhao *Xiaoqing Long Xiaoqing Long Jisheng Wang Jisheng Wang
  • Mianyang Third People's Hospital, Mianyang, China

The final, formatted version of the article will be published soon.

    The aim of this study was to assess the association between dietary folate intake and severe headache or migraine.Examination Survey (NHANES) data from 1999 to 2004. Weighted logistic regression models, restricted cubic spline (RCS) regression, sensitivity analysis, and stratified analyses were performed to evaluate the association between dietary folate intake and severe headache or migraine.Results: A total of 4107 participants were included, with 704 individuals (17.14%) experienced severe headache or migraine. After adjusting for all covariates, an independent association was found between dietary folate intake and severe headache or migraine (OR=0.77, 95% CI: 0.64-0.93, P=0.005). When folate intake was categorized, individuals in Q2 (251.21-356.00 μg/d), Q3 (356.19-514.00 μg/d), and Q4 (≥515.00 μg/d) had ORs of 0.95 (95% CI: 0.75-1.20, P=0.660), 0.86 (95% CI: 0.67-1.12, P=0.266), and 0.65 (95% CI: 0.48-0.89, P=0.007), respectively, compared to those in Q1 (≤251.00 μg/d). The RCS regression showed a linear negative relationship between dietary folate intake and severe headache or migraine. Stratified and sensitivity analyses yielded similar results.There was a linear negative relationship between dietary folate intake and migraine.

    Keywords: Folate, severe headache or migraine, Logistic regression, Restricted cubic spline regression, Cross-sectional study

    Received: 28 Jun 2024; Accepted: 13 Nov 2024.

    Copyright: © 2024 Zhao, Long and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dehua Zhao, Mianyang Third People's Hospital, Mianyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.