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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1454880
This article is part of the Research Topic Nutrients, Stress Response, and Human Health View all 5 articles

Association of Triglyceride-Glucose Index and Its Combination with Obesity Indicators in Predicting the Risk of Aortic Aneurysm and Dissection

Provisionally accepted
Wangqin Yu Wangqin Yu 1Xiaoling Wang Xiaoling Wang 2Zhongyan Du Zhongyan Du 1Wenke Cheng Wenke Cheng 1*
  • 1 Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China
  • 2 Lintong Rehabilitation and Recuperation Center, Shanxi, China

The final, formatted version of the article will be published soon.

    The association between the triglyceride-glucose (TyG) index and its combination with obesity indictors in aortic aneurysm and dissection (AAD) remains unclear. We aimed to investigate the association between TyG and TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TyG-waist height ratio (TyG-WHtR) and AAD risk.Methods: This study included 387,483 baseline participants from the UK Biobank with complete data on TyG, TyG-BMI, TyG-WC and TyG-WHtR. Cox proportional hazard models evaluated the relationship between these four indicators and the risk of AAD occurrence. Restricted cubic spline (RCS) examined the non-linear relationship between these indicators and AAD risk, while receiver operating characteristic (ROC) curves assessed the predictive value of these four indicators for AAD risk.Results: Over a median follow-up of 13.7 years, 3041 AAD events were recorded. Multivariate Cox regression analysis indicated that for each standard deviation increase, the risk of AAD occurrence increased by 33% (HR:

    Keywords: TyG, TyG-BMI, TyG-WC, TyG-WHtR, Aortic aneurysm and dissection, UK Biobank

    Received: 25 Jun 2024; Accepted: 09 Oct 2024.

    Copyright: © 2024 Yu, Wang, Du and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wenke Cheng, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.