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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1454364
This article is part of the Research Topic Dietary Strategies for Managing Hypertension and Hypotension: Insights and Mechanisms View all 5 articles

Circulating Fatty Acids, Genetic Susceptibility and Hypertension: A Prospective Cohort Study

Provisionally accepted
Lingling Lu Lingling Lu 1Xiaoli Gu Xiaoli Gu 1Daheng Yang Daheng Yang 1Bingjian Wang Bingjian Wang 2龙广凤 G. Long 龙广凤 G. Long 1*
  • 1 Nanjing Children's Hospital, Nanjing, Jiangsu Province, China
  • 2 Huai'an First People's Hospital, Huai'an, Jiangsu, China

The final, formatted version of the article will be published soon.

    Background: Combining genetic risk factors and plasma fatty acids (FAs) can be used as an effective method of precision medicine to prevent hypertension risk.: A total of 195,250 participants in the UK Biobank cohort were included in this study from 2006--2010. Polygenic risk scores (PRSs) were calculated for hypertension using single-nucleotide polymorphisms (SNPs). Concentrations of plasma FAs, including polyunsaturated fatty acids (PUFAs), monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs), were tested by nuclear magnetic resonance. The Cox model was used to test for the main effects of PRS, different plasma FAs and their joint effects on hypertension. Relative excess risk due to interaction (RERI) and the attributable proportion due to interaction (AP) were used to test the additive interaction.

    Keywords: Plasma fatty acids, Hypertension, Polygenic risk score, Additive interaction, cohort study

    Received: 25 Jun 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Lu, Gu, Yang, Wang and Long. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: 龙广凤 G. Long, Nanjing Children's Hospital, Nanjing, Jiangsu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.