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SYSTEMATIC REVIEW article

Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1451386

Dietary total antioxidant capacity and risk of stroke: A systematic review and dose-response meta-analysis of observational studies

Provisionally accepted
Yiqian Huang Yiqian Huang Yajun Ni Yajun Ni Lin Yu Lin Yu Long Shu Long Shu Qin Zhu Qin Zhu Xing-Zhen He Xing-Zhen He *
  • Zhejiang Hospital, Hangzhou, China

The final, formatted version of the article will be published soon.

    Background: Previous studies have reported the association between dietary total antioxidant capacity (TAC) and risk of stroke, but these findings have been inconsistent.We therefore performed this systematic review and dose-response meta-analysis of observational studies to evaluate the association between dietary TAC and risk of stroke.Methods: A systematic literature search was carried out through PubMed, ISI Web of Science, EBSCO, Scopus and China National Knowledge Infrastructure (CNKI) databases, to find the relevant articles published up to 31 May, 2024. Random-effects or fixed-effects models were used to pool the relative risks(RRs) and their 95% confidence intervals(CIs) where appropriate.Heterogeneity across studies were determined using the Cochran's Q test and I-square(I 2 ) statistics.Results: Eight observational studies (six cohort and two case-control studies) were included in the final analysis. The pooled results showed that higher intake of dietary TAC was associated with a lower risk of stroke (RR=0.88; 95%CI: 0.81-0.95, P=0.002). Additionally, dose-response analysis of cohort studies demonstrated a linear association between dietary TAC intake and risk of stroke (RR=0.994; 95%CI: 0.990-0.999, Pnonlinearity=0.329, Pdose-response=0.014). Subgroup analyses showed the inverse association between dietary TAC intake and risk of stroke in the studies with mean age<50 (RR=0.82, 95%CI: 0.67-0.99, P=0.044), and there was no evidence of heterogeneity (P=0.360; I 2 =0.0%). Conclusions: Our findings indicated that higher intake of dietary TAC was inversely associated with the risk of stroke. Future studies in particular of longitudinal design are needed to confirm this inverse relationship.

    Keywords: Dietary total antioxidant capacity, Stroke, Systematic review, dose-response meta-analysis, Observational studies

    Received: 19 Jun 2024; Accepted: 10 Sep 2024.

    Copyright: © 2024 Huang, Ni, Yu, Shu, Zhu and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xing-Zhen He, Zhejiang Hospital, Hangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.