Skip to main content

SYSTEMATIC REVIEW article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1451342

The association between blood selenium and metabolic syndrome (MetS) in adults: A systematic review and dose-response metaanalysis of epidemiologic studies

Provisionally accepted
Zahra Hajhashemy Zahra Hajhashemy 1*Sahar Foshati Sahar Foshati 2Mohammad Bagherniya Mohammad Bagherniya 1Gholamreza Askari Gholamreza Askari 1
  • 1 Isfahan University of Medical Sciences, Isfahan, Iran
  • 2 Shiraz University of Medical Sciences, Shiraz, Fars, Iran

The final, formatted version of the article will be published soon.

    Background and Aim: Although the relationship between selenium and metabolic syndrome (MetS) was previously investigated, the findings were inconsistent. Therefore, we performed a systematic review and dose-response meta-analysis to summarize the association between blood selenium and MetS in adults. Methods: A comprehensive search was conducted in Medline (PubMed), ISI Web of Science, Scopus, and motor engineering of Google Scholar up to October 1st, 2024. Observational studies which reported the risk of MetS in relation to blood selenium in adults were included. Results: Overall, 16,779 participants and 6,471 cases with MetS from 5 cross-sectional and 7 case-control studies were included in the current systematic review and meta-analysis. The findings showed that participants with the highest blood values of selenium (mean: 268.5 µg/L) in comparison to those with the lowest values (mean:75.27 µg/L) had 40% higher risk of MetS. Nevertheless, this association was not significant (95%CI: 0.99- 1.97). Due to a significant between-study heterogeneity (I2 = 90.4%, P <0.001), subgroup analysis was conducted based on potential confounders. However, this association was only significant in a few subgroups with low number effect sizes. Linear dose-response analysis illustrated each 50 μg/L increment in circulating selenium was related to 7% higher risk of MetS (RR:1.07, 95%CI: 0.99,1.15) However, this association was not statistically significant. Additionally, non-linear dose-response analysis indicated a U-shaped association between blood selenium and risk of MetS with the lowest risk at 160 ug/L of blood selenium (P<0.001). Conclusion: There is a U-shaped relationship between blood selenium levels risk of MetS. However, more longitudinal studies are needed to verify the causality of findings and clarify the underlying mechanisms.

    Keywords: Selenium, metabolic syndrome, adults, Systematic review, dose-response, Meta-analysis

    Received: 22 Jul 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Hajhashemy, Foshati, Bagherniya and Askari. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zahra Hajhashemy, Isfahan University of Medical Sciences, Isfahan, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.