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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 |
doi: 10.3389/fnut.2024.1448938
This article is part of the Research Topic Preventative Medicine: Nutritional and Lifestyle Interventions for Healthy Ageing and Chronic Diseases View all 12 articles
Negative Association Between Body Roundness Index and Bone Mineral Density: Insights from NHANES
Provisionally accepted
Ziyao Ding
1,2
Zhe Zhuang
1,2
Rongze Tang
1,2*
Xinzhe Qu
1,2*
Zicheng Huang
3*
Maji Sun
1,2*
Feng Yuan
1,2*- 1 Xuzhou Medical University, Xuzhou, China
- 2 Department of Spine Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
- 3 Shanghai Jiao Tong University, Shanghai, Shanghai Municipality, China
Background: Osteoporosis (OP), affecting millions around the globe, is a prevalent degenerative condition of the bones characterized by a decrease in bone mineral density (BMD) and an increase in bone fragility. A novel anthropometric measure, the Body Roundness Index (BRI), provides a more accurate assessment of body fat distribution compared to traditional metrics. Using data from the National Health and Nutrition Examination Survey (NHANES), this study aims to explore the relationship between BRI and total BMD in U.S. adults aged 20 and above.Methods: Data from NHANES (2011-2018) were examined, encompassing 9,295 participants following exclusions. Dual-energy X-ray absorptiometry (DXA) was employed to measure BMD. BRI was calculated using waist circumference (WC) and height. The study accounted for variables such as demographic traits, physical exam results, lab test findings, and survey responses. Weighted multivariable linear regression models and smooth curve fitting methods were utilized to assess the relationship between BRI and total BMD.The research found a notable inverse relationship between BRI and total BMD. In the model with full adjustments, an increase of one unit in BRI was linked to a 0.0313 g/cm² reduction in total BMD (P < 0.0001). Moreover, an inflection point was identified at BRI = 9.5229, where each one-unit rise in BRI beyond this threshold corresponded to a more substantial decrease in total BMD (0.0363 g/cm²). Analysis by subgroups revealed that this negative association was consistent across most demographic and health-related categories.The results demonstrate a notable inverse relationship between BRI and 2 total BMD, indicating that a higher BRI could be associated with lower BMD and a potentially greater risk of developing OP. This underscores the significance of accounting for body fat distribution in preventing OP and advocates for the use of BRI as a valuable marker for early intervention approaches.
Keywords: Body Roundness Index (BRI), Bone Mineral Density (BMD), Osteoporosis, NHANES, Obesity
Received: 14 Jun 2024; Accepted: 24 Jul 2024.
Copyright: © 2024 Ding, Zhuang, Tang, Qu, Huang, Sun and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rongze Tang, Xuzhou Medical University, Xuzhou, China
Xinzhe Qu, Xuzhou Medical University, Xuzhou, China
Zicheng Huang, Shanghai Jiao Tong University, Shanghai, 200240, Shanghai Municipality, China
Maji Sun, Xuzhou Medical University, Xuzhou, China
Feng Yuan, Xuzhou Medical University, Xuzhou, China
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