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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1447524
This article is part of the Research Topic Micronutrients and Metabolic Diseases-Volume II View all 5 articles

Associations of dietary sources of antioxidant intake and NAFLD：NHANES 2017-2020 and Mendelian randomization

Provisionally accepted
ZiLong Yue ZiLong Yue 1Ziming Jiang Ziming Jiang 2*Long Qian Long Qian 3*Lele Li Lele Li 4*Xianliang Qi Xianliang Qi 1*Kaifeng Hu Kaifeng Hu 4*
  • 1 Guoyang Branch of Anhui Provincial Hospital, Bozhou, Anhui, China
  • 2 Shanghai Tenth People's Hospital, Tongji University, Shanghai, Shanghai Municipality, China
  • 3 Wuhu Hospital of Traditional Chinese Medicine, Wuhu, Anhui Province, China
  • 4 First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, China

The final, formatted version of the article will be published soon.

    Purpose: To determine the association between dietary antioxidant sources and non-alcoholic fatty liver disease (NAFLD).Methods:In this observational study, we utilized NHANES 2017-2020 data to identify the factors associated with NAFLD in dietary antioxidant sources via weighted multivariate logistic regression models. Then, Mendelian randomization (MR) was applied to investigate the effect of dietary antioxidant sources on NAFLD at the genetic level.Results: Of the six dietary sources of antioxidants, only Vitamin E (Vit E) was significantly associated with NAFLD (OR=0.98; 95% CI: 0.97 -0.99; p = 0.001) . Upon adjusting for all covariates, it was determined that the highest quartile of dietary Vit E intake was associated with a decreased NAFLD occurrence compared with the lowest quartile of dietary Vit E intake (P<0.001).The results of IVW-MR analysis revealed an association between Vit E and NAFLD (OR = 0.028; p = 0.039).Conclusions: Our research indicates a negative and linear relationship between daily vitamin E intake and NAFLD.

    Keywords: Dietary sources of antioxidant, Non-alcoholic fatty liver disease, NHANES, Vitamin E, Mendelian randomization

    Received: 11 Jun 2024; Accepted: 21 Oct 2024.

    Copyright: © 2024 Yue, Jiang, Qian, Li, Qi and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Ziming Jiang, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200070, Shanghai Municipality, China
    Long Qian, Wuhu Hospital of Traditional Chinese Medicine, Wuhu, Anhui Province, China
    Lele Li, First Affiliated Hospital of Wannan Medical College, Wuhu, 241001, Anhui Province, China
    Xianliang Qi, Guoyang Branch of Anhui Provincial Hospital, Bozhou, Anhui, China
    Kaifeng Hu, First Affiliated Hospital of Wannan Medical College, Wuhu, 241001, Anhui Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.