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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Sport and Exercise Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1446944
This article is part of the Research Topic Food and Nutrition for Athletics: Redefining the Role and Application View all 4 articles

Effects of nano-Rhodiola rosea combined with treadmill exercise on anti-exercise fatigue in rats

Provisionally accepted
Jibing Wang Jibing Wang Guoyan Zhang Guoyan Zhang Duona Wang Duona Wang Yuanyuan Yan Yuanyuan Yan Qin Yang Qin Yang *
  • Tongji University, Shanghai, China

The final, formatted version of the article will be published soon.

    OBJECTIVE: To explore the potential strategies and mechanisms for enhancing the bioavailability of Rhodiola rosea. METHODS: 36 Sprague-Dawley rats(8-weeks-old) were randomly assigned to six groups (n=6 per group). Groups Ⅰ and Ⅱ received nano-dose forms of R rosea, groupsⅢ and Ⅳ received normal dose form of R rosea, and groups Ⅴ and Ⅵ served as distilled water control groups. Groups II, IV, and VI were combined with moderateintensity treadmill exercise. Each group received a daily gavage with 0.5 ml of nano -R rosea solution (0.01 mg/ml), normal R rosea solution, and distilled water. All rats were subjected to exhaustive swimming after 4 weeks. Outcome measures include GSH-px activity, T-AOC activity, MDA content, hepatic glycogen content, and T-SOD activity.RESULTS: For plasma MDA content, group I was lower than group III (p<0.01) and group V (p<0.01), group II was lower than group III (p<0.01), group VI was higher than group II (p<0.05) and group IV (p<0.05). For plasma T-AOC activity, group II was higher than group VI (p<0.01). For plasma GSH-px activity, group I was lower than group IV (p<0.05), groups II, III, and IV were higher than group V (p<0.05), and group V was lower than that of group VI (p<0.05). For T-SOD activity of quadriceps muscle, groups I and III were higher than that in group V (p<0.05).CONCLUSION: R rosea has a positive effect on anti-exercise fatigue in rats, with the nano-dosage form of R rosea showing more significant efficacy than the normal form especially combined with aerobic exercise.

    Keywords: Rhodiola rosea, nano, anti-exercise fatigue, Free radical, antioxidant enzyme

    Received: 10 Jun 2024; Accepted: 26 Aug 2024.

    Copyright: © 2024 Wang, Zhang, Wang, Yan and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qin Yang, Tongji University, Shanghai, China

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