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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1445369
This article is part of the Research Topic Micronutrients and Metabolic Diseases-Volume II View all 3 articles

Associations of minerals intake with colorectal cancer risk in the Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial

Provisionally accepted
Siyue Li Siyue Li Qingqian Ren Qingqian Ren Baixue Liu Baixue Liu Zixuan Song Zixuan Song Dan Wang Dan Wang Yanna Shang Yanna Shang Hao Wang Hao Wang *
  • Zhengzhou University, Zhengzhou, China

The final, formatted version of the article will be published soon.

    Abstract Objective: Exploring the association between common mineral intake and the risk of colorectal cancer (CRC). Methods: We utilized the multivariate Cox proportional hazards model to assess the association between intake of minerals and the risk of CRC, estimating hazard ratios (HRs) and 95% confidence intervals (CIs). Results: A total of 101,686 eligible participants were included in the analysis of this study, including 1,100 CRC cases. After adjusting for potential confounders, we found that total zinc intake (HRQ4vs.Q1: 0.79, 95%CI 0.67-0.93; P for trend < 0.05), iron intake (HRQ4vs.Q1: 0.81, 95%CI 0.68-0.96; P for trend < 0.05), copper intake (HRQ4vs.Q1: 0.80, 95%CI 0.68-0.95; P for trend < 0.05), selenium intake (HRQ4vs.Q1: 0.83, 95%CI 0.69-0.98; P for trend < 0.05) were significantly negatively associated with the incidence of CRC, but magnesium intake in the appropriate range is associated with a reduced risk of CRC (HRQ3vs.Q1: 0.77, 95%CI 0.65-0.91; P for trend > 0.05). Conclusions: Our findings suggested that an appropriate intake of total zinc, iron, copper, selenium and magnesium were associated with lower CRC risk.

    Keywords: Minerals, colorectal cancer, PLCO, Zinc, Iron, Magnesium, Copper, Selenium

    Received: 07 Jun 2024; Accepted: 12 Aug 2024.

    Copyright: © 2024 Li, Ren, Liu, Song, Wang, Shang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hao Wang, Zhengzhou University, Zhengzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.