Skip to main content

REVIEW article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1445080
This article is part of the Research Topic Functional Foods for Metabolic Health View all articles

Polyphenols alleviate metabolic disorders: the role of ubiquitinproteasome system

Provisionally accepted
Wei Gu Wei Gu 1Guohuo Wu Guohuo Wu 1*Guijie Chen Guijie Chen 1Xianghui Meng Xianghui Meng 2*Shanbao Cai Shanbao Cai 2*Zhongwen Xie Zhongwen Xie 1*
  • 1 Anhui Agricultural University, Hefei, China
  • 2 The First Affiliated Hospital of University of Science and Technology of China, Hefei, China

The final, formatted version of the article will be published soon.

    Metabolic disorders include obesity, nonalcoholic fatty liver disease, insulin resistance and type 2 diabetes. It has become a major health issue around the world. Ubiquitin-proteasome system (UPS) is essential for nearly all cellular processes, functions as a primary pathway for intracellular protein degradation. Recent researches indicated that dysfunctions in the UPS may result in the accumulation of toxic proteins, lipotoxicity, oxidative stress, inflammation, and insulin resistance, all of which contribute to the development and progression of metabolic disorders. An increasing body of evidence indicates that specific dietary polyphenols ameliorate metabolic disorders by preventing lipid synthesis and transport, excessive inflammation, hyperglycemia and insulin resistance, and oxidative stress, through regulation of the UPS. This review summarized the latest research progress of natural polyphenols improving metabolic disorders by regulating lipid accumulation, inflammation, oxidative stress, and insulin resistance through the UPS. In addition, the possible mechanisms of UPS-mediated prevention of metabolic disorders are comprehensively proposed. We aim to provide new angle to the development and utilization of polyphenols in improving metabolic disorders. FIGURE 1. Graphic abstract: Mechanisms of polyphenols target UPS to prevent metabolic disorders. Polyphenols alleviate metabolic disorders by modulating E3 ubiquitin ligases and the 26S proteasome to mitigate insulin resistance, oxidative stress, abnormal lipid metabolism, and inflammatory responses through regulating the ubiquitin-proteasome system.

    Keywords: Polyphenols, metabolic disorders, ubiquitin-proteasome system, nonalcoholic fatty liver disease, Lipid Metabolism, Inflammation

    Received: 06 Jun 2024; Accepted: 04 Jul 2024.

    Copyright: © 2024 Gu, Wu, Chen, Meng, Cai and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Guohuo Wu, Anhui Agricultural University, Hefei, China
    Xianghui Meng, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China
    Shanbao Cai, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China
    Zhongwen Xie, Anhui Agricultural University, Hefei, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.