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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Immunology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1443895
This article is part of the Research Topic Nutrients, Stress Response, and Human Health View all 4 articles

Omega-3 fatty acids abrogates oxido-inflammatory and mitochondrial dysfunction-associated apoptotic responses in testis of tamoxifen-treated rats

Provisionally accepted
Adeyemi Odetayo Adeyemi Odetayo 1*Roland Akhigbe Roland Akhigbe 2Moses hamed Moses hamed 3Tolulope Oluwole Tolulope Oluwole 4Morufu Balogun Morufu Balogun 1Luqman Olayaki Luqman Olayaki 5
  • 1 Federal University of Health Sciences, Ila-Orangun, Ila Orangun, Nigeria
  • 2 Ladoke Akintola University of Technology, Ogbomosho, Oyo, Nigeria
  • 3 Afe Babalola University, Nigeria, Nigeria
  • 4 Crescent University, Abeokuta, Nigeria
  • 5 University of Ilorin, Ilorin, Kwara, Nigeria

The final, formatted version of the article will be published soon.

    BACKGROUND: Tamoxifen (TAM) is a widely used drug in patients with gynecomastia and breast cancer. TAM exerts its anticancer effects via its antiestrogenic activities. Unfortunately, TAM has been reported to exert gonadotoxic effects on male testes. Therefore, this study was designed to explore the possible associated mechanisms involved in TAM-induced testicular dysfunction and the possible ameliorative effects of omega-3 fatty acids (O3FA). METHODOLOGY: Animals were randomly divided into control, O3FA, TAM, and TAM + O3FA. All treatment lasted for 28 days. RESULTS: TAM exposure impaired sperm qualities (count, motility, and normal morphology) and decreased testicular 3β-HSD and 17β-HSD. It was accompanied by a decline in serum testosterone and an increase in estradiol, luteinizing and follicle-stimulating hormones.These observed alterations were associated with an increase in testicular injury markers, oxidoinflammatory response, and mitochondria-mediated apoptosis. These observed alterations were ameliorated by O3FA treatments. CONCLUSIONS: O3FA ameliorated TAM-induced testicular dysfunction in male Wistar rats by modulating XO/UA and Nrf2/NF-kb signaling and cytochrome c-mediated apoptosis in TAM-treated rats.

    Keywords: anticancer drugs, Nrf2 (nuclear factor erythroid 2-related factor 2) and NF-κB (nuclear factor-kappa B) signaling, Selective Estrogen Receptor Modulators, Testicular function, cytochrome c

    Received: 05 Jun 2024; Accepted: 19 Jul 2024.

    Copyright: © 2024 Odetayo, Akhigbe, hamed, Oluwole, Balogun and Olayaki. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Adeyemi Odetayo, Federal University of Health Sciences, Ila-Orangun, Ila Orangun, P.M.B. 204, Nigeria

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.