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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1438319
This article is part of the Research Topic Nutrition and Metabolism in Cancer: Role in Prevention and Prognosis View all 21 articles

A Novel Integrated Nutrition-combined Prognostic Index for Predicting Overall Survival after Radical Gastrectomy

Provisionally accepted
Xiang Li Xiang Li 1*Jun Zhang Jun Zhang 2Jinming Xu Jinming Xu 3Ke Li Ke Li 3Lianwei Wang Lianwei Wang 3Zhongxue Fu Zhongxue Fu 1*
  • 1 Third Affiliated Hospital of Chongqing Medical University, Chongqing, China
  • 2 Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
  • 3 Department of Gastrointestinal Surgery, Chongqing University Fuling Hospital, Chongqing, China, Chongqing, China

The final, formatted version of the article will be published soon.

    Objective: The objectives of this study were to integrate the Prognostic Nutritional Index, Controlling Nutritional Status, and Nutritional Risk Index, into a novel Nutrition-combined Prognostic Index (NCPI), and to develop and validate a nomogram to predict overall survival (OS) in patients with gastric cancer (GC). Materials and methods: Data from 609 patients with GC, collected between January 1, 2017, and April 30, 2023, were retrospectively analyzed. Optimal cut-off values for nutritional parameters were determined using X-Tile software, and the Kaplan-Meier method applied for survival analysis. Univariate, least absolute shrinkage and selection operator, and multivariate Cox regression analyses were conducted, and a nomogram for predicting OS in patients with GC constructed and validated. Results: Inferior nutritional status was strongly correlated with worse clinicopathologic features and prognosis of patients with GC. NCPI, body mass index, American Joint Committee on Cancer T stage, and lymph node ratio were identified as independent risk factors for OS. A nomogram including these factors predicted 1-, 3-, and 5-year OS, with training and validation set C-index values of 0.716 and 0.77, respectively. Calibration curves demonstrated that the predicted outcomes closely matched the actual results, and decision curve analysis highlighted the high practical value of the model. Conclusion: The novel nutritional marker, NCPI, is closely associated with the clinicopathologic features and OS of patients with GC. The practical value of the NCPI-based nomogram was demonstrated and a web-based calculator developed.

    Keywords: gastric cancer, nutrition-combined prognostic index, nomogram, overall survival, nutrition

    Received: 25 May 2024; Accepted: 05 Nov 2024.

    Copyright: © 2024 Li, Zhang, Xu, Li, Wang and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiang Li, Third Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Zhongxue Fu, Third Affiliated Hospital of Chongqing Medical University, Chongqing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.