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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1437521

Association between Dietary Patterns and the Prognosis of Amyotrophic Lateral Sclerosis in China: A Cross-Sectional Study

Provisionally accepted
Xun Xu Xun Xu 1Yuwei Huang Yuwei Huang 1Yue Zhu Yue Zhu 1Qing-Wen Jin Qing-Wen Jin 1,2*
  • 1 1 Nanjing Medical University, Nanjing, Jiangsu Province, China
  • 2 Sir Run Run Hospital, Nanjing Medical University, Nanjing, Liaoning Province, China

The final, formatted version of the article will be published soon.

    Recently, a growing number of studies have specifically examined the impact of dietary variables on the development and progression of ALS. The purpose of this study was to investigate the correlation between different dietary patterns and Chinese ALS patients' prognosis. A retrospective study was conducted by recruiting 590 patients with ALS who attended and were regularly followed at hospitals in Nanjing from 2016 to 2023. Nutrient intake was calculated using dietary information collected through the food frequency questionnaire (FFQ), and patients were divided into a control group and special diet groups, including a high-calorie group (HC), a high-protein group (HP), and a ketogenic diet group (KD), based on their specific intake. Patients in the HP had a better nutritional status. And the disease progression rate (ΔFS) was significantly associated with dietary patterns, with the KD group having the lowest ΔFS. Meanwhile, special diets extended the survival time of stage 4 patients but had no effect on the overall survival of the disease. Therefore, a special diet can be one of effective options for patients with advanced ALS. Patients with poor nutritional status may choose the HP diet, whereas those with underlying conditions should consider the ketogenic diet with caution.

    Keywords: Amyotrophic Lateral Sclerosis, special dietary patterns, Nutritional Status, Disease progression rate, prognostic factors

    Received: 26 Jun 2024; Accepted: 16 Oct 2024.

    Copyright: © 2024 Xu, Huang, Zhu and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qing-Wen Jin, 1 Nanjing Medical University, Nanjing, Jiangsu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.