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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1436450

Dietary intakes of branch chained amino acids and obesity risk among Chinese gestational diabetes women

Provisionally accepted
Gang Hu Gang Hu 1*xiaoyun yang xiaoyun yang 2Weiqin Li Weiqin Li 3huikun liu huikun liu 3leishen wang leishen wang 3junhong leng junhong leng 3yuxin fan yuxin fan 2Xilin Yang Xilin Yang 4Ming Liu Ming Liu 2
  • 1 Pennington Biomedical Research Center, Baton Rouge, United States
  • 2 Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China
  • 3 Tianjin Women and Children’s Health Center, Tianjin, China
  • 4 School of Public Health, Tianjin Medical University, Tianjin, China

The final, formatted version of the article will be published soon.

    Introduction: Epidemiological studies have assessed the correlation between daily dietary branch chain amino acid (BCAA) intakes and the risk of obesity, however, the findings from these studies were inconsistent and investigations among GDM women were few.Objective: The present study was to investigate the associations of daily BCAA intakes with the risks of overweight and abdominal obesity among women with prior gestational diabetes mellitus (GDM) postpartum.We performed a cross-sectional study of 1263 women with prior GDM at 1-5 years post-delivery. Logistic regression models were used to estimate the associations of daily dietary intakes of BCAAs with the risks of overweight and abdominal obesity.The multivariable-adjusted odds ratios (ORs) across quartiles of daily BCAA intakes postpartum were 1.42 (95% confidence interval [CI] 1.02-1.97), 1.00 (reference), 1.21 (95% CI 0.88-1.68), and 1.31 (95% CI 0.95-1.81) for general overweight, and 1.38 (95% CI 0.99-1.90), 1.00, 1.19 (95% CI 0.86-1.64), and 1.43 (95% CI 1.04-1.98) for abdominal obesity, respectively. Women with the lowest quartile of daily BCAA intakes significantly increased the risks of general overweight (OR 1.49; 95 %CI 1.06-2.09) and abdominal obesity (OR 1.50; 95 %CI 1.08-2.11) compared with women at quartile 2 of daily BCAA intakes after further adjustment of daily energy intake.The present study indicated that daily lower BCAA intakes were associated with increased risks of general overweight and abdominal obesity among women with prior GDM.

    Keywords: branched chain amino acids, Obesity, gestational diabetes mellitus, Postpartum, Overweight

    Received: 22 May 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Hu, yang, Li, liu, wang, leng, fan, Yang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Gang Hu, Pennington Biomedical Research Center, Baton Rouge, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.