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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Microbes
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1435778
This article is part of the Research Topic Food-Derived Phytochemicals as Regulators of Gut Microbiota View all 3 articles

Effects of saponins R b1 and R e in American ginseng intervention on Intestinal microbiota of aging model

Provisionally accepted
Mao Shi Mao Shi 1HongXiu Fan HongXiu Fan 2*HongCheng Liu HongCheng Liu 2*Yanrong Zhang Yanrong Zhang 2*
  • 1 Jilin Provincial Center for Disease Control and Prevention (JPCDC), Changchun, China
  • 2 Jilin Agriculture University, Changchun, Jilin Province, China

The final, formatted version of the article will be published soon.

    Aging brings about physiological dysfunction, disease, and eventual mortality. An increasing number of studies indicate that aging can easily lead to dysbiosis of the gut microbiota, which can further affect digestion, nerves, cognition, emotions, and more. Therefore, gut bacteria play an important role in regulating the physical functions of aging populations.While saponins, the primary components of American ginseng, are frequently utilized for treating common ailments in the elderly due to their potent antioxidant properties, there is a scarcity of comprehensive studies on aging organisms.This study focused on 18 month old aging mice and investigated the effects of single intervention and combined intervention of Rb1 and Re, the main components of Panax quinquefolium saponins, on the gut microbiota of aging mice.High throughput 16s RNA gene sequencing analysis was performed on the gut contents of the tested mice, and the results showed that Rb1 and Re had a significant impact on the gut microbiota. Rb1, Re, and Rb1+Re can effectively enhance the diversity of gut microbiota, especially in the combined Rb1+Re group, which can recover to the level of young mice. Re can promote the abundance of probiotics such as Lactobacillus, Lactobacillaceae, and Lactobacillus, and inhibit the abundance of harmful bacteria such as Enterobacteriaceae. This indicates that the intervention of Rb1, Re, and Rb1+Re can maintain the homeostasis of gut microbiota, and the combined application of Rb1+Re has a better effect.The relationship between aging, brain gut axis, and gut microbiota is very close. Saponins can improve the gut microbiota of aging individuals by maintaining the balance of gut microbiota and the normal function of the brain gut axis, enabling the body to achieve a gut microbiota homeostasis closer to that of young healthy mice.

    Keywords: Aging, American ginseng, Rb1, re, intestinal microbiota

    Received: 21 May 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Shi, Fan, Liu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    HongXiu Fan, Jilin Agriculture University, Changchun, 130118, Jilin Province, China
    HongCheng Liu, Jilin Agriculture University, Changchun, 130118, Jilin Province, China
    Yanrong Zhang, Jilin Agriculture University, Changchun, 130118, Jilin Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.