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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1435775
This article is part of the Research Topic Preventative Medicine: Nutritional and Lifestyle Interventions for Healthy Ageing and Chronic Diseases View all 9 articles

The Negative Association between The Docosapentaenoic Acid Intake and The Incidence of AMD Baesd on NHANES 2005-2008

Provisionally accepted
Baiwei Xu Baiwei Xu 1,2,3Yi Hu Yi Hu 1,2,3*Jie Di Jie Di 1,2,3*Zhongwei Liu Zhongwei Liu 4*Ziyan Yu Ziyan Yu 1,2,3Lin Han Lin Han 1,2,3*Yuan Ning Yuan Ning 1,2,3*
  • 1 Department of Ophthalmology, Fourth Affiliated Hospital of China Medical University, Liaoning Province, China
  • 2 Eye Hospital of China Medical University, Shenyang, Liaoning Province, China
  • 3 Key Lens Research Laboratory of Liaoning Province, Shenyang, Liaoning Province, China
  • 4 Department of Anesthesiology, Shengjing Hospital, China Medical University, Shenyang, Liaoning Province, China

The final, formatted version of the article will be published soon.

    Age-related macular degeneration(AMD) is an ophthalmic disease that causes visual impairment and is one of the leading causes of blindness in the elderly. Fatty acids are essential nutrients required by the body and play a cornerstone role in the life activities of the body. Many studies have reported that fatty acids are involved in the development of AMD. To confirm this association, we conducted the present study. We analyzed the association between all fatty acid intake and AMD using National Health and Nutrition Examination Survey(NHANES) data from 2005-2008. Quantile regression was performed to assess the effect of fatty acids on AMD at different intake levels. After adjusting for covariates, only saturated fatty acids showed no significant difference between AMD patients and non-AMD patients(23.64g vs. 26.03g, p=0.052). Total fat(70.88g vs. 78.86g, p=0.024), monounsaturated fatty acids(25.87g vs. 28.95g, p=0.019), polyunsaturated fatty acids(15.10g vs. 17.07g, p=0.017) showed significant differences between the two groups. When AMD was considered as an outcome, the association between AMD and docosaentaenoic acid(DPA) was negative in the multivariate logic model (model 1: OR =＜0.001, 95% CI =＜0.001~0.734; model 2: OR=＜0.001, 95% CI =＜0.001~0.002; model 3: OR= ＜0.001 , 95% CI = ＜0.001~0.002). In the quantile regression, DPA was shown to be negatively associated with the presence of AMD only in the fourth quartile in model 2 and model 3 (model 2: OR= ＜0.001, 95% CI =＜0.001~0.927; model 3: OR= ＜0.001 , 95% CI = ＜0.001~0.775). Therefore, based on above results, we concluded that DPA intake could prevent the development of AMD.

    Keywords: age-related macular degeneration (AMD), Cross-sectional study, national Health and Nutrition Examination Survey (NHANES), fatty acid, Docosapentaenoic acid (DPA)

    Received: 21 May 2024; Accepted: 12 Jul 2024.

    Copyright: © 2024 Xu, Hu, Di, Liu, Yu, Han and Ning. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yi Hu, Department of Ophthalmology, Fourth Affiliated Hospital of China Medical University, Liaoning Province, China
    Jie Di, Department of Ophthalmology, Fourth Affiliated Hospital of China Medical University, Liaoning Province, China
    Zhongwei Liu, Department of Anesthesiology, Shengjing Hospital, China Medical University, Shenyang, 110004, Liaoning Province, China
    Lin Han, Department of Ophthalmology, Fourth Affiliated Hospital of China Medical University, Liaoning Province, China
    Yuan Ning, Department of Ophthalmology, Fourth Affiliated Hospital of China Medical University, Liaoning Province, China

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