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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1434704
This article is part of the Research Topic Optimizing Hydration: Advances in Understanding, Assessment, and Promotion View all 7 articles

The Impact of Coffee Consumption on Osteoarthritis: Insights from NHANES and Mendelian Randomization Analysis

Provisionally accepted
Kai Feng Kai Feng Peng Li Peng Li Haohui Guo Haohui Guo Zhirong Chen Zhirong Chen *
  • General Hospital of Ningxia Medical University, Yinchuan, China

The final, formatted version of the article will be published soon.

    Background: Osteoarthritis (OA) is a prevalent degenerative joint condition, and emerging evidence suggests that dietary factors, such as coffee consumption, may influence its risk. However, the relationship between coffee consumption and the risk of developing OA remains ambiguous. This study aims to explore the association between coffee intake and OA complemented by Mendelian Randomization (MR) to infer causality.We analyzed data from 32,439 participants across ten NHANES cycles (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018), including 3,676 individuals diagnosed with OA. Osteoarthritis was diagnosed through a structured questionnaire, while coffee consumption was assessed via 24-hour dietary recalls.Participants were categorized based on reported coffee intake: 0 cups, <2 cups, 2-4 cups, and >4 cups per day. We employed weighted multivariable logistic regression to examine associations between coffee consumption and OA by using data from the NHANES 1999-2018, adjusting for various covariates. Subsequently, a MR analysis was conducted using genetic variants as instrumental variables to infer causal relationships, with multiple methods including inverse-variance weighted (IVW) analysis, MR-Egger regression, and weighted median techniques to assess the robustness, heterogeneity, and potential pleiotropy of our findings.Results: Our regression models indicated an increased risk of OA with rising coffee consumption, with significant associations noted particularly for those consuming more than 4 cups daily (OR = 1.19, 95% CI: 1.00-1.41, p = 0.049). In MR analysis, coffee intake was causally linked to OA types, demonstrating increased risk for knee OA (KOA:

    Keywords: Coffee consumption1, osteoarthritis2, mendelian randomization3, NHANES4, crosssectional study5

    Received: 21 May 2024; Accepted: 14 Nov 2024.

    Copyright: © 2024 Feng, Li, Guo and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhirong Chen, General Hospital of Ningxia Medical University, Yinchuan, China

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