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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1433570

Causal effect of lifestyle and metabolic indicator with herpes zoster: a two-sample Mendelian randomization study

Provisionally accepted
Mingsheng Huang Mingsheng Huang 1Yiheng Liu Yiheng Liu 2Cheng Chen Cheng Chen 3*
  • 1 Department of Neurosurgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
  • 2 Department of Cardiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
  • 3 Department of Intensive Care Unit, Jianyang Traditional Chinese Medicine Hospital, Chengdu, China

The final, formatted version of the article will be published soon.

    Background Previous observational studies have reported certain causal relationships between factors such as smoking, alcohol consumption, obesity, physical activity, metabolic disorders, and the incidence of herpes zoster (HZ). However, there is controversy regarding the observed results across different studies. Our objective was to investigate the causal effects of these risk factors on the risk of herpes zoster through a Mendelian randomization analysis using two-sample bidirectional approaches. Methods We conducted two-sample bidirectional Mendelian randomization analyses to explore the causal relationships between different lifestyles, obesity assessment indices, metabolic indicators, and the risk of herpes zoster. All exposure and outcome data were sourced from publicly available data from genome-wide association studies. Results In the inverse-variance weighted (IVW) analysis, body mass index (BMI) (OR: 1.160, 95% CI: 1.030-1.307, P = 0.014), Body fat percentage (BFP) (OR: 1.241, 95% CI: 1.050-1.467, P = 0.011), and whole body fat mass (WBFM) (OR: 1.199, 95% CI: 1.057-1.362, P = 0.005) exhibited positive associations with the risk of HZ. However, usual walking pace (UWP) (OR: 0.498, 95% CI: 0.254-0.976, P = 0.042) demonstrated a significant negative correlation with HZ risk. Other factors including alcohol intake frequency, smoking initiation, smoking status, insomnia, and sleep duration did not show significant causal relationships with HZ. Conclusion Mendelian randomization studies revealed that BMI, BFP, and WBFM are risk factors for HZ. UWP showed a protective effect against HZ. These findings provide

    Keywords: Risk factors, Metabolic indicator, Herpes Zoster, Mendelian randomization, Causal effect

    Received: 16 May 2024; Accepted: 31 Jul 2024.

    Copyright: © 2024 Huang, Liu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Cheng Chen, Department of Intensive Care Unit, Jianyang Traditional Chinese Medicine Hospital, Chengdu, China

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