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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrigenomics
Volume 11 - 2024 |
doi: 10.3389/fnut.2024.1432289
The relationship between lipoproteins and the risk of Esophageal cancer: A Mendelian randomization study
Provisionally accepted- 1 Shanxi Medical University, Taiyuan, China
- 2 The Gynecology and Obstetrics Dpartment, Shanxi Provincial People's Hospital, Taiyuan, Shanxi Province, China
- 3 The Radiotherapy Dpartment, Shanxi Provincial People's Hospital, Taiyuan, Shanxi Province, China
Esophageal cancer (EC) causes approximately 508,000 deaths annually, making it a significant cause of cancer-related mortality. While previous studies have suggested an association between lipoprotein levels and EC risk, the causal relationship remains unexplored. This study aims to investigate the causal link between lipoproteins and EC using Mendelian randomization (MR).This study employed MR to determine the causal effect between lipoproteins and EC risk, with body mass index (BMI) used as a confounder in multivariable MR (MVMR) analysis. Sensitivity analyses were conducted to assess the reliability of the results. Univariable MR (UVMR) analysis indicated that low-density lipoprotein (LDL) had a significant inverse association with EC risk (P=0.03; OR=0.89; 95% CI 0.73-0.98), while high-density lipoprotein (HDL) and triglycerides showed no significant association. In the synthesis of findings across diverse datasets, LDL maintained a notable inverse association with the likelihood of EC (P<0.001; OR=0.89; 95%CI 0.84-0.94). Triglyceride levels indicated a potential trend towards an adverse correlation with EC susceptibility (P=0.03; OR=-0.94; 95%CI 0.89-0.99), whereas HDL levels did not establish a definitive causal link with the occurrence of EC. MVMR analysis, adjusting for BMI, confirmed these findings. LDL exhibits a clear inverse causal relationship with EC risk, regardless of BMI adjustment. No causal effects were observed for HDL in relation to EC risk. Meanwhile, there is a small but statistically significant causal relationship between triglycerides and EC risk.
Keywords: esophageal cancer, Low density lipoprotein, high density lipoprotein, triglyceride, Mendelian randomization, BMI
Received: 13 May 2024; Accepted: 16 Aug 2024.
Copyright: © 2024 Cui, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rong Zhang, The Gynecology and Obstetrics Dpartment, Shanxi Provincial People's Hospital, Taiyuan, 030012, Shanxi Province, China
Lei Li, The Radiotherapy Dpartment, Shanxi Provincial People's Hospital, Taiyuan, 030012, Shanxi Province, China
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